摘要
目的：研究骨形态发生蛋白对喉软骨缺损的修复作用．方法：兔甲状软骨中部手术切除５ｍｍ×６ｍｍ全层软骨作为喉软骨缺损的动物模型，采用骨形态发生蛋白（ＢＭＰ）与陶瓷化骨颗粒复合作修复材料，动态观察缺损区修复情况．结果：２周时缺损区内已有软骨基质形成，４周时软骨断端形成管状骨，１６周时缺损区已全部被新生骨组织充填．而对照组仅有少量的软骨生成．结论：ＢＭＰ复合物可在甲状软骨缺损区内较快地诱导软骨和骨形成，从而修复软骨缺损．
Aim:Tostudytheefectofbovinebonemorphogeneticprotein(bBMP)ontherepairofthyroidcartilagedefect.Methods:BMPboundtoceramizedbovinebonegranuleswasimplantedin25adultrabbitswith5mm×6mmsurgicalydefectsinthemiddleofthyroidcartilages.CeramicxenogenicbonegranuleswithoutBMPwereimplantedintothecontralateralthyroidcartilagesascontrols.Rabbitswerekiledatthe2nd,4th,8th,12thand16thweekafterimplantationandthethyroidcartilageswerehavestedforlightmicroscopestudy.Results:Thedefectsintheexperimentalgroupsin16weekswerecompletelyrepairedbynewcartilagesandboneswhilethecontrolswerefiledwithfibrousconnectivetissues.TherewasnoobservableforeignbodyreactioninthecombinedBMPgraft.Conclusion:BMPcompoundappearstohaveastrongabilityininducingcartilageandboneregenerationinthedefectofthyroidcartilage,whichwouldbeusedinclinicalpractice.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
1996年第S1期21-22,共2页
Chinese Journal of Trauma
关键词
骨形态发生蛋白
甲状软骨
修复
BonemorphogeneticproteinThyroidcartilageRepair
