摘要
目的： 探讨缺氧缺血性脑病（ＨＩＥ） 新生儿血中内皮素（ＥＴ）和一氧化氮（ＮＯ） 的变化及意义。方法： 采用放射免疫分析法和硝酸还原酶法测定２０ 例ＨＩＥ新生儿和２０ 例正常新生儿血浆ＥＴ与血清ＮＯ水平。结果：新生儿ＨＩＥ急性期血浆ＥＴ水平明显高于恢复期及对照组（ Ｐ均＜０．０１）；ＨＩＥ急性期血清ＮＯ水平明显低于恢复期及对照组（ Ｐ均＜ ０．０１） 。结论：ＥＴ、ＮＯ参与新生儿ＨＩＥ的病理生理过程。
Objective: To probe into the changes and significance of serum endothelin (ET) and nitric oxide(NO) levels in hypoxic ischemic encephalopathy(HIE) of the newborn. Methods: Plasma ET levels were determined by using a radioimmunoassay kit, serum NO levels were determined by using a nitrate reductase method in 20 newborn with HIE and 20 normal newborn. Results: Plasma ET levels in acute period of the disease were significantly higher than those in recovery period and in control group (P<0.01). Serum NO levels in acute period of the disease were significantly lower than those in recovery period and in control group(P<0.01).Conclusion: ET and NO participates in the pathophysiology process of hypoxic ischemic encephalopathy of the newborn.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
1999年第S1期30-32,共3页
Journal of Sun Yat-Sen University:Medical Sciences
基金
中山医科大学孙逸仙纪念医院科研基金
