摘要
制备粒径均一、单分散、生物可降解的载药微球对于研发缓控释注射微球具有重要的应用价值。本文重点阐述了在制备粒径均一的单分散微球方面已取得成绩的SPG膜乳化法、微流体技术、电喷雾法和声波激发雾化法的技术原理、应用现状、影响因素、技术要点及尚存在的问题等。
The preparation of uniform-sized, monodisperse and biodegradable drug-loaded microspheres has important value of application in the field of the research and development of sustained- and controlled-release injectable microspheres. The principles, applications, influence factors, technical points and remaining problems of SPG membrane emulsification technique, microfluidic technology, electrospray and acoustic excitation atomized technique are reviewed. The above methods have reached certain achievements in preparing uniform-sized and monodisperse microspheres.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2011年第11期856-862,870,共8页
Chinese Journal of Pharmaceuticals
关键词
粒径均一
单分散
微球
SPG膜乳化法
微流体技术
电喷雾法
声波激发雾化法
综述
uniform-sized
monodisperse
microsphere
SPG membrane emulsification technique
microfluidictechnology
electrospray
acoustic excitation atomized technique
review
作者简介
付寒（1987-），女，硕士研究生，专业方向：缓控释制剂与靶向制剂。Tel：020-39943343E-mail：fhsunnyl26@163．com
通信联系人：吴传斌（1963-），男，博士生导师，从事缓控释制剂与靶向制剂研究。Tel：020-39943117E-mail：cbwu2000@yahoo．com
