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复发性阿弗他溃疡患者TNF-α的表达及临床意义 被引量:6

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摘要 目的:研究肿瘤坏死因子(TNF-α)在复发性阿弗他溃疡患者血清中的表达及临床意义。方法:采用双抗体夹心ELISA法对60例复发性阿弗他溃疡患者(分为轻型、重型、疱疹样阿弗他溃疡三种血清中TNF-α的含量进行了检测,并以30例健康人血清做对照。结果:三组复发性阿弗他溃疡60例患者中TNF-α的平均含量均比健康人TNF-α的平均含量明显升高(P<0.05),且重型阿弗他溃疡患者(99.51±31.35)pg/mL和疱疹样阿弗他溃疡患者(74.51±16.38)pg/mL,TNF-α平均含量均明显高于轻型(59.54±16.92)pg/mL,即重型>疱疹样型>轻型。结论:复发性阿弗他溃疡患者血清中TNF-α的含量明显高于健康对照,说明TNF-α参与了其病理过程。
出处 《长治医学院学报》 2011年第5期375-377,共3页 Journal of Changzhi Medical College
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  • 1Femiano F, Lanza A, Buonaiuto C, et al. Guidelines for diagnosis and management of aphthous stomatitis. Pediatr infect Dis J,2007,26(8) : 728-732.
  • 2李秉琦,周曾同.口腔黏膜病学[M].2版.北京:人民卫生出版社,2004.
  • 3Lewkowicz N, Lewkowicz P, Kurnatowska A, et al. Innate immune system is implicated in recurrent aphthous ulcer pathogenesis. J Oral Pathol Med. 2003,32(8) :475-81.
  • 4Natah SS, Hiyrinen-Immonen R, Hietanen J, et al. Immu- nolocalization of tumor necrosis factor-alpha expressing cells in recurrent aphthous ulcer lesions (RAU). J Oral Pathol Med,2000, 29(1) :19-25.
  • 5王娟.肿瘤坏死因子α在大鼠脑外伤后急性胃黏膜病变中的作用[J].世界华人消化杂志,2007,15(12):1437-1440. 被引量:4
  • 6Sun A,Wang JT,Chia JS, et al. Levamisole can modulate the serum tumor necrosis factor--alpha level in patients with recurrent aphthous ulcerations. J Oral Pathol Med,2006,35(2)~111-116.

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  • 1王建滨,孙正,关晓兵,谢美慧.康复新液治疗复发性阿弗他溃疡近期疗效观察[J].临床口腔医学杂志,2007,23(1):52-54. 被引量:42
  • 2张振康,樊明文,傅民魁.现代口腔医学[M].北京:北京科技出版社,2003:729—732.
  • 3李秉琦,周曾同.口腔黏膜病学[M].第2版.北京:人民卫生出版社,2004.49-55.
  • 4于世凤.口腔组织病理学[M].4版.北京:北京人民卫生出版社.2001.167.
  • 5Aikawa NE, Gonqalves C, Silva CA, et al. Late response to anti - TNF - ct therapy in refractory mucocutaneous lesions of Behqet- dis- ease[J]. Rheumatol lnt, 2011,31(8) :1097 -9.
  • 6Ficarra G, Baroni G, Massi D. Pyostomatitis vegetans: cellular im- mune profile and expression of IL- 6, IL -8 and TNF -alpha [ J ]. Head Neck Pathol, 2010,4( 1 ) :1 -9.
  • 7A1 - Samadi A, Kouri VP, Salem A, et al. IL - 17C and its recep- tor IL - 17RA/IL - 17RE identify human oral epithelial cell as an inflammatory cell in recurrent aphthous ulcer [ J ]. J Oral Pathol Med, 2014,43(2) :117 -24.
  • 8Aikawa NE,Gonalves C,Silva CA,et al.Late response to anti-TNF-αtherapy in refractory mucocutaneous lesions of Behet's disease[J].Rheumatol Int,2011,31(8):1097.
  • 9Epstein JB, Emerton S, Guglietta A, et al. Assessment of epidermal growth factor in oral secretions of patients receiving radiation[ J]. O- ral Oncol, 1997,33 ( 33 ) :359 - 363.
  • 10Eisen D, Lynch DP. Selecting topical and systemic agents for recur- rent aphthous stomatitis[ J]. Cutis ,2001,68 ( 3 ) :201 - 206.

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