摘要
目的:探讨有氧运动对老年大鼠学习记忆能力、血清睾酮及海马CA1区nNOS表达的影响。方法:选择SD雄性老年大鼠,分成老年对照组及有氧训练组。对照组不运动,有氧训练组采用递增负荷训练,连续8周。8周后检测血清睾酮,测试大鼠空间学习记忆能力,对海马CA1区nNOS神经元的数量、面积及灰度进行测量和分析。结果:1)与老年对照组比较,有氧运动组大鼠血清睾酮水平增高(P<0.05),完成八臂迷宫时间缩短,错误次数显著减少(P<0.05);2)与老年对照组比较,有氧运动组海马CA1区nNOS免疫阳性细胞数量和阳性产物面积均增加(P<0.05)。结论:有氧运动可提高老年大鼠的记忆能力,机理可能与长期有氧运动提高老年大鼠的血清睾酮水平及增强大脑海马CA1区nNOS的表达有关。
Objective：To explore the influence of the aerobic training on learning and memory,the level of serum testosterone,and expression of nNOS within Hippocampus CA1 of brain in the aged rats.Methods：SD aged rats（24-mouth） were chosen and randomly divided into 2 groups：the aged control group and the aerobic training group.The control group kept normal activities and the aerobic training group undertook the 8-week training with progressively increasing load.Then each animal＇s capability of learning and memory and the level of serum testosterone were examined,and nNOS expression within Hippocampus CA1 was detected and analyzed.Results：1） Compared with the aged group,the level of testosterone of blood plasma increased（P0.05）,the time of completing 8-arms radial maze shortened（P0.05）,error frequency significantly decreased（P0.05） in the aerobic training group;2）Compared with the aged group,the amount and area of nNos within Hippocampus CA1 obviously increased（P0.05） in the aerobic training group.Conclusion：The aerobic training may enhance the learning and memory ability of the aged rats,and its mechanism might be that aerobic training increase the level of serum testosterone and reinforced expression of nNOS within Hippocampus CA1 at the same time.
出处
《体育科学》
CSSCI
北大核心
2011年第11期43-47,60,共6页
China Sport Science
基金
国家自然科学基金项目(30671019)
作者简介
付芳（1978-），女，山西人，讲师，硕士，研究方向为运动与中医康复，E-mail：lionlian007@163．com；
崔建梅（1972-），女，河北人，讲师，硕士，研究方向为运动与中医康复；
于芳（1968-），女，山西人，教授，硕士，硕士研究生导师，研究方向为运动与中医康复。
