摘要
炎性纤维性息肉(inflammatory fibroid polyp,IFP)是发生在消化道的少见疾病,有关其成因和疾病性质一直存在争论。近年来针对IFP的分子生物学研究发现其存在PDGFRα基因激活突变,因此部分学者认为IFP是一种伴有PDGFRα基因突变的良性肿瘤。对PDGFRα基因在肿瘤发生中作用的认识,将为进一步研究伴有PDGFRα基因突变的肿瘤和临床靶向治疗提供理论基础。
Inflammatory fibroid polyp（IFP） is a rare disease in digestive tract.The reports on the pathogenesis and property for IFP are controversy all the time.Recently,activating mutations in PDGFRα gene were reported in IFP,so some scholars considered that IFP is a benign mesenchymal tumor rather than a reactive lesion.To know about the effect of PDGFRα gene on the genesis of tumor will lay a foundation for the clinical treatment and further studing PDGFRα gene-associated tumors.
出处
《国际病理科学与临床杂志》
CAS
2011年第5期453-456,共4页
Journal of International Pathology and Clinical Medicine
基金
南京市青年科技人才启动项目(QYK11164)~~
作者简介
孙琦，硕士，医师，主要从事消化道肿瘤病理研究
通信作者：樊祥山，E-mail：fanxiangshan@yahoo．com．cn
