摘要
目的探讨不同浓度白酒对大鼠血脂的影响及与脑血管病的关系。方法采用酶法测定高浓度灌酒组、中浓度灌酒组及灌水对照组大鼠血总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,分析各组大鼠血脂水平与大鼠脑血管病的关系。结果高、中浓度灌酒组大鼠血TC、TG、LDL-C水平均高于灌水对照组(P<0.05),高浓度组更为显著(P<0.05);高浓度组HDL-C水平低于灌水对照组(P<0.05),中浓度组变化不明显(P>0.05)。脑血管形态学观察,大鼠血脂水平升高(TC、TG、LDL-C)/降低(HDL-C)程度与脑血管病变程度之间存在浓度效应关系。结论慢性灌酒可使大鼠血TC、TG、LDL-C水平升高,高浓度灌酒组更为明显;高浓度灌酒组HDL-C降低,中浓度灌酒组变化不明显。大鼠血TC、TG、LDL-C升高水平或HDL-C降低水平与脑血管病变程度之间存在浓度效应关系,说明长期酗酒可使血TC、TG、LDL-C水平升高和HDL-C水平降低,进而导致脑血管出现病变,且浓度越高危害性越大。
Objective To investigate the influence of different doses of spirits on rat＇s blood lipids and cerebrovascular disease.Methods Rats were divided into three groups.The first group was treated with high concentration of alcohol,the second group with middle concentration of alcohol and the third was the control group.The levels of total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,and low density lipoprotein cholesterol（LDL-C） in blood and the relationship between lipid levels and cerebral vascular disease were analyzed.Results The average levels of TC,TG,LDL-C in blood in the high and middle concentration groups were higher than those of the control group（P0.05）.These levels high concentration group was significantly different（P0.05）;the level of HDL-C in high concentration group was below the level of the control group（P0.05）,the level in middle concentration group did not change significantly（P0.05）.Observation of brain morphology showed that there was a dose-response relationship between the extent of cerebral vascular disease and the high and low levels of blood lipid.Conclusions Levels of TC,TG,LDL-C in blood rose after chronic alcoholism.It was found that in high concentration of alcoholism group,levels of HDL-C in blood decreased obviously while it did not change significantly in the middle concentration group.There was a dose-response relationship between the extent of cerebral vascular disease and the high and low levels of blood lipid.Chronic alcoholism increased the levels of TC,TG,LDL-C and reduced HDL-C level in blood,which led to the cerebro vascular lesions.
出处
《佛山科学技术学院学报（自然科学版）》
CAS
2011年第4期27-30,共4页
Journal of Foshan University(Natural Science Edition)
基金
国家自然科学基金资助项目(30772458)
关键词
白酒
血脂
脑血管病
wine
blood lipids
cerebrovascular disease
作者简介
汪家文（1981-），男，广东佛山人，佛山科学技术学院助教。
通讯作者：于晓军（1959-），男，吉林市人，汕头大学教授，博士生导师。
