摘要
目的探讨甘精胰岛素(GL)或中性鱼精蛋白锌胰岛素(NPH)联合阿卡波糖对老年糖尿病的疗效和治疗前后对胰岛功能的影响。方法对42例初诊老年糖尿病患者分别于睡前注射GL(23例)或NPH(19例),口服阿卡波糖,观察8周前后空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹C肽和餐后C肽的变化。结果二组均有明显的降血糖作用,但GL组发生的低血糖事件更少,C肽水平明显提高。结论应用GL和NPH睡前注射均对老年糖尿病的疗效较好,但GL的低血糖发生率低,且可改善胰岛功能。
[ Objective ] To evaluate the efficacy of glargine insulin （GL） or neutral protamine hagedom （NPH） combined with acarbose on glucose metabolism and the influence of b-cell function in the old patients with type 2 diabetes. [Methods] 42 newly diagnosed were randomly divided into 2 groups, treated acarbose plus GL （n =23） or NPH （n =19）. The change of fasting blood glucose, postprandial blood glucose, HbAle and C peptide in beth groups after 8-week treatment were compared. [Results] The daily glucose profile dropped obviously in both groups. Hypogleyemia occurred less frequently and serum C peptide level increased in glargine group.[Conclusions] Both of the 2 groups have the significant effects on controlling the blood glucose. And GL has better effect on reducing risk of hyperglycemia and improving islet function.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2011年第18期2181-2183,共3页
China Journal of Modern Medicine
关键词
甘精胰岛素
糖尿病
阿卡波糖
胰岛功能
glargine insulin
diabetes mellitus
acarbose
islet b-cell function
