摘要
目的探讨125碘(125I)粒子植入联合化疗治疗中晚期肺癌的临床价值。方法选择不同病理类型中晚期非小细胞肺癌181例:CT引导下经皮穿刺植入125I粒子,3d后给予顺铂+吉西他滨化疗(Ⅰ组,26例);单纯给予顺铂+吉西他滨化疗(Ⅱ组,66例);在给予50～70Gy外照射同时给予顺铂+吉西他滨化疗(Ⅲ组,89例)。治疗6个月后评价3组疗效及毒副作用。结果Ⅰ组有效率76.9%(20/26),其中完全缓解率(CR)7.7%(2/26),部分缓解率(PR)69.2%(18/26),无效率(NC)15.4%(4/26),进展率(PD)7.7%(2/26);Ⅱ组有效率53.0%(35/66),其中CR、PR、NC、PD分别为3.0%(2/66)、50.0%(33/66)、31.8%(21/66)和15.2%(10/66);Ⅲ组有效率84.3%(75/89),其中CR、PR、NC、PD分别为7.9%(7/89)、71.9%(64/89)、16.9%(15/89)和3.3%(3/89)。Ⅱ组与Ⅰ、Ⅲ组有效率比较,差异有统计学意义(P<0.05),Ⅲ组与Ⅰ组有效率比较,差异无统计学意义(P>0.05)。粒细胞减少发生率Ⅰ、Ⅱ、Ⅲ组分别为38.5%(10/26)、34.8%(23/66)、60.7%(54/89),Ⅰ组与Ⅱ组比较差异无统计学意义(P>0.05),Ⅲ组与Ⅰ、Ⅱ组比较差异有统计学(P<0.05)。结论 125I粒子植入联合化疗治疗晚期肺癌有效率高,且毒副作用低。
Objective To study the clinical value of iodine-125 seed implantation combined chemotherapy for advanced lung cancer.Methods A total of 181 cases of different pathological types of non-small cell lung cancer were divided into three groups.Group Ⅰ（26 cases） was percutaneously implanted with iodine-125 seeds using CT guide,and then was given cisplatin plus gemcitabine after 3 days.GroupⅡ（66 cases） was treated with cisplatin plus gemcitabine chemotherapy only.Group Ⅲ（89 cases） received radiotherapy（50-70 Gy） combined with cisplatin plus gemcitabine chemotherapy.The therapeutic effects and side effects were evaluated 6 months after treatment.Results The effective rate,complete response rate（CR）,partial response rate（PR）,noneffective rate（NR） and progressive disease rate（PD） were,respectively,76.9%（20/26）,7.7%（2/26）,69.2%（18/26）,15.4%（4/26） and 7.7%（2/26） in group Ⅰ,53.0%（35/66）,3.0%（2/66）,50.0%（33/66）,31.8%（21/66） and 15.2%（10/66） in group Ⅱ,and 84.3%（75/89）,7.9%（7/89）,71.9%（64/89）,16.9%（15/89） and 3.3%（3/89） in group Ⅲ.The effective rate in group Ⅱ was remarkably lower than that in group Ⅰ and group Ⅲ（P0.05）,but there were no significant differences between group Ⅲ and group Ⅰ（P0.05）.The incidence of granulocytopenia in group Ⅲ（60.7%,54/89） was significantly higher than that in groupⅠ（38.5%,10/26） and groupⅡ（34.8%,23/66）（P0.05）,but there were no significant differences between group Ⅰand group Ⅱ（P0.05）.Conclusion Iodine-125 seed implantation combined chemotherapy is effective for advanced lung cancer with minimal side effects.
出处
《南昌大学学报（医学版）》
CAS
2011年第8期60-62,65,共4页
Journal of Nanchang University：Medical Sciences
基金
江西省卫生厅科技计划项目(20063181)
关键词
125I粒子
化疗
放疗
中晚期肺癌
iodine-125 seeds
chemotherapy
radiotherapy
advanced lung cancer
作者简介
陈志军（1968-），男，学士，主任医师，主要从事肿瘤核医学及治疗核医学研究。
