摘要
目的观察雾化吸入利多卡因对中重度急性发作的支气管哮喘患者肺功能的影响,评价利多卡因治疗哮喘的疗效和安全性。方法将60例中重度急性发作期哮喘患者随机分为两组,在继续常规治疗基础上,治疗组雾化吸入利多卡因100mg,对照组雾化吸入生理盐水5ml。分别于吸入前、吸入后15min、30min、60min、90min测第1秒用力呼气量(FEV1)、峰值呼气流速(PEF),评价临床疗效,记录不良反应。结果治疗组在吸入后30min、60min、90min的FEV1、PEF、有效率均高于对照组(P<0.05)。吸入利多卡因后无严重不良反应发生。结论在常规治疗基础上,雾化吸入利多卡因能改善中重度急性发作哮喘患者的肺功能,缓解临床症状,不良反应少。
Objective To observe the effect of aerosol inhalation of lidocaine on lung function of bronchial asthma patients with acute moderate/severe exacerbation,and evaluate its curative effect and safety.Methods 60 cases of asthma patients with acute moderate/severe exacerbation were divided into 2 groups randomly.On the base of routine treatment,100mg of aerosol lidocaine was inhaled in the treatment group,while 5ml of normal saline was inhaled in the control group.Forced expiratory volume in 1 second（FEV1） and peak expiratory flow（PEF） were measured before inhalation（as baselines） and at 15,30,60,90 minute after nebulization.In the meantime,clinical effects were evaluated,and the adverse reaction were recorded.Results FEV1,PEF,and effective rate in the treatment group were higher than that in the control group at 30,60,90 minute after inhalation（P〈0.05）.No severe adverse reaction occurred.Conclusion On the base of routine treatment,aerosol inhalation of lidocaine improved lung function,relieved symptom of asthma patients with acute moderate/severe exacerbation,and had small adverse reaction.
出处
《四川医学》
CAS
2011年第10期1577-1578,共2页
Sichuan Medical Journal
关键词
支气管哮喘
利多卡因
雾化吸入
肺通气功能
bronchial asthma
lidocaine
aerosol inhalation
lung ventilation function
