摘要
微小RNA（microRNA，miRNA）是一类对基因具有调控功能的内源性非编码小分子RNA。目前认为miRNA在多种生物学过程中起着至关重要的作用，包括细胞增殖、分化、凋亡等。近年研究表明miRNA表达异常能导致疾病甚至肿瘤的发生，有类似于抑癌基因或癌基因的功能。因此，对miRNA的进一步研究为肿瘤的诊断和治疗开辟了新的路径。
MicroRNA （miRNA） is a family of endogenous, non-coding small RNAs molecules that function as gene regulators. It has been revealed that miRNAs may play a critical role in many biological processes including cell proliferation, differentiation and apoptosis. Recent studies demonstrate that aberrant expression of miRNAs can lead to several human diseases even cancer. These tiny but potent molecules have the function as anti-oncogene or oncogene. Accordingly, further study of miRNAs has opened a novel avenue in the diagnosis and of human cancer.
出处
《国际肿瘤学杂志》
CAS
2011年第9期649-652,共4页
Journal of International Oncology
关键词
肿瘤
微RNAS
基因表达调控
Neoplasms
MicroRNAs
Gene expression regulation
作者简介
通信作者：焦炳华，E-mail：jiaobh@uninet．com．cn
