摘要
目的：观察新辅助化疗对Ⅲ、Ⅳ期胃癌的疗效.方法：将2002年1月-2009年1 2月行新辅助化疗的Ⅲ、Ⅳ期胃癌患者49例（新辅助化疗组）,与同期未接受新辅助化疗Ⅲ、Ⅳ期胃癌患者75例（对照组）进行对照分析.结果：新辅助化疗组总有效率为55.1%（27/49 ）,TMN分期降期转好19例（39%）;手术切除率83.6%（41/49）,其中根治性手术35例（71.4%）,姑息性手术14例（28.6%）.对照组手术切除率为78%（74/95）,其中根治性手术43例（58%）,姑息性手术31例（42%）.结论：Ⅲ、Ⅳ期胃癌患者接受新辅助化疗,可提高手术切除率,改善预后.
Objective To evaluate the effect of neoadjavunt chemotherapy to m or IV stage gastric carcinoma. Method 49 cases ofⅢ or Ⅳstage gastric carcinoma patients from 2002 to 2009 who received neoadjuvant chemotherapy were included, and 95 cases who did not received neoadjuvant chemotherapy were compared as control. Results The total efficiency of neoadjuvant chemotherapy was 55.1% （27 cases）. 19 cases （39%） had got downstaging . The rate of resection was 83.6% （41 cases ）, and the radical rate was 71.4% （35 cases）, 14 （28.6% were received palliative resection. In the control group, the rate of resection was 78 % （74 cases ）, the radical rate was 58 % （43 cases）, 31 （42%） received palliative resection . Conclusion Neoadjuvant chemotherapy could effectively raise the radical rate in Ⅲor Ⅳ stage gastric carcinoma patients, and improve the prognosis of these patients.
关键词
进展期胃癌
新辅助化疗
Ⅲor Ⅳstage gastric earcinoma
Neoadjuvant
chemotherapy
