期刊文献+

奥氮平治疗精神分裂症血药浓度与临床疗效的关系 被引量:6

原文传递
导出
摘要 奥氮平对精神分裂症的阳性、阴性症状均有良好疗效,较少引起锥体外系反应,因而在临床广泛应用。由于奥氮平的药代动力学参数个体差异较大,因此监测奥氮平血药浓度,探讨血药浓度与临床疗效的关系,将有助于提高疗效、减少不良反应。本研究对奥氮平治疗精神分裂症的血药浓度与疗效、剂量、副反应的关系进行了初步研究。
出处 《中国基层医药》 CAS 2011年第18期2548-2550,共3页 Chinese Journal of Primary Medicine and Pharmacy
  • 相关文献

参考文献5

  • 1Callaghan JT, Bergstrom RF, Ptak LR, et al. Olanzapine :pharmaco- kinetic and pharmacodynamic profile. Clin Pharmacokinet, 1999, 37(3) :177-193.
  • 2唐亚芳,宋伟明,吴柳松.反相高效液相色谱法测定人血清中奥氮平浓度[J].中国药业,2007,16(21):46-47. 被引量:2
  • 3Fellows L, Ahmad F, Castle D J, et al. Investigation of target plas- maconcentration-effect relationships for olanzapine in schizophre- nia. Therapeutic Drug,2003,25 ( 6 ) :682-689.
  • 4Perry PJ, Land BC, Sanger T, et al. Olanzapine plasma concentra- tions and clinical response:acute phase results of the North Ameri- can olanzapine trial. J Clin Psychopharmacol,2001 ;21 ( 1 ) :14-20.
  • 5张明廉,袁国桢,姚建军,钱永潮,倪素琴,刘雨生,蒋辛衍,周德祥.精神分裂症患者奥氮平治疗的血药浓度与剂量及临床效应的关系[J].中华精神科杂志,2003,36(3):139-142. 被引量:12

二级参考文献15

  • 1李娜,许秀峰.奥氮平的药理学和临床应用[J].云南医药,2004,25(6):520-524. 被引量:9
  • 2杨玲玲.影响药物作用的因素和临床用药原则[A].见:王祖新主编.临床精神药理学[C].北京:北京医科大学、中国协和医科大学联合出版社,1990.62-68.
  • 3Sanger TM, Lieberman JA, Tohen M, et al. Olanzapine versus haloperidol treatment in first episode psychosis. Am J Psychiatry,1999,156:79-87.
  • 4Tollefson GD, Sanger riM. Negative symptoms: a path analytic approach to a double-build, placebo and haloperidol controlled clinical trial with olanzapine, Am J psychiatry, 1997,154:466-474.
  • 5Olesen OV, linet K. Determination of olanzapine in serum by HPLC using ultraviolet detection considering the easy oxidability of the compound and the presence of other psychotropic drugs. J Chromatogr B Biomed Sci Appl,1998,714:309-315.
  • 6Midha KIC Intersubjeet variation in the pharmacokinetics of haloperidol and reduced holoperidol. J Clin Psychoparmacol, 1999,9:98-99.
  • 7Perry PJ, Sanger T, Beasley C. Olanzapine plasma concentrations and clinical response in acutely schizophrenic patients. J Chin Psychopharmacol, 1997,17:472-477.
  • 8Beasley CM, Tollefson GD, Tran PV. Safety of olanzapine. J clin Psychiatry, 1997,58 Suppl 10:13-17.
  • 9Bergmann N,Frich A,Parzer P,et al.Olanzapine plasma concentration,average daily dose,and interaction with co-medication in schizophrenic patients[J].Pharmacopsychiatry,2004,37 (2):63.
  • 10Olesen OV,Linnet K.Determination of olanzapine in serum by HPLC using ultraviolet detection considering the easy oxidability of the compound and the pesence of other psychotropic drugs[J].J Chromatogr B,1998,714:309.

共引文献12

同被引文献68

引证文献6

二级引证文献39

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部