摘要
目的探讨抗幽门螺杆菌（HP）在特发性血小板减少性紫癜（ITP）治疗中的作用。方法145例HP阳性ITP患者根据血小板计数分为血小板小于50×10^9及血小板大于50×10^9两组。血小板小于50×10^9／LHP阳性患者95例，按人院顺序随机分为联合治疗组与单用糖皮质激素组。联合治疗组给予根除HP及糖皮质激素治疗，单用糖皮质激素组未给予根除HP治疗，其余治疗同联合治疗组。血小板大于50×10^9／LHP阳性、无明显出血征象者50例，按入院顺序随机分为抗HP治疗组与对照组。抗HP治疗组进行单纯正规抗HP治疗，对照组未用任何药物治疗，定期复查血常规。结果联合治疗组总有效率（92％）明显高于单用糖皮质激素治疗组（75％）（X2=5．01，P〈0．05），2年内复发率（19％）明显低于单用糖皮质激素组（49％）（x2=9．69，P〈0．01）。单纯根除HP治疗对ITP患者有一定疗效。结论根除HP是合并HP感染的ITP患者行之有效的治疗方法。
Objective To investigate clinical effect of eradication of helicobacter pylori in patients with idio- pathic thrombocytopcnic purpura（ITP）. Methods 145 cases with HP-positive ITP paitients were divided into two groups（ platelet counts results 〈50 ×10^9/L and platelet counts results 〉50 ×10^9/L）. 95 cases with platelet counts 〈 50 ×10^9/L were divided into two groups and treated with prednisone and Hp eradication（48 cases） or with predni- sone without Hp eradication（47 cases）. 95 cases with platelet counts 〉 50 ×10^9/L were divided into two groups and treated with Hp eradication 25 cases） or follow-up without any treatment （25 cases）. Results The total effective rate in group treated with prednisone and Hp eradication was significantly higher than that in group with prednisone without Hp eradication（92% vs 75%, X2 = 5.01 ,P 〈 0.05 ）. The recurrence rate in two year in group treated with prednisone and Hp eradication was significantly lower than that in group with prednisone without Hp eradication（ 19% vs 49%, x2 = 9. 69, P 〈 0. 01 ）. HP eradicatiaon single can improve platelet counts in HP-positive ITP paitients. Conclusion The detection and eradication of H pylori infection should be considered in patients with ITP. H. pylofi eradication could be used for initial treatment in HP-positive ITP paitients.
出处
《中国基层医药》
CAS
2011年第18期2497-2499,共3页
Chinese Journal of Primary Medicine and Pharmacy
