摘要
目的探讨慢性阻塞性肺疾病(COPD)患者,医院感染的危险因素及病原学特点。方法采用病例对照的方法,调查2006年7月-2008年8月,在呼吸内科病房发生医院感染的COPD患者,做1∶1配对。结果 COPD患者医院感染的独立危险因素为住院天数(OR=5.838)和留置导管(OR=4.487),而雾化吸入糖皮质激素为保护性因素(OR=0.067);医院感染的部位以下呼吸道多见占78.0%;病原菌中革兰阴性菌占52.3%,革兰阳性菌占35.8%,真菌占11.9%。结论对部分COPD急性加重期患者,雾化吸入糖皮质激素可减少医院感染的发生,加强医务人员的手卫生及规范化操作、严格掌握留置导管指征、尽可能缩短住院天数,对减少医院感染有一定意义。
OBJECTIVE To explore the risk factors and etiology of nosocomial infections in patients with chronic obstructive pulmonary disease.METHODS Retrospective analysis was carried out to investigate the cases of nosocomial infection of patients with chronic obstructive pulmonary disease in the department of respiratory medicine from Jul 2006 to Aug 2008,A 1∶1 matched case control study was conduced.RESULTS The independent risk factors were days of hospitalization（OR=5.838） and indwelling catheters（OR=4.487）.Aerosol Inhalation of glucocorticosteroid was a protective factor（OR=0.067）.Lower respiratory tract infection was frequent（78.0%）.The pathogenic bacteria were mainly Gram-negative bacilli（52.3%） and then Gram-positive cocci（35.8%）,fungi（11.9%）.CONCLUSION Aerosol inhalation of glucocorticosteroid can reduce the rate of nosocomial infection in some patients with acute exacerbation of COPD.It is also important to emphasize hands hygiene and standardized operation of medical staff,to manage indwelling catheters strictly and reduce the duration of hospitalization as short as possible.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第18期3829-3831,共3页
Chinese Journal of Nosocomiology
基金
上海市嘉定区科委资助课题2006(JKK024)
关键词
慢性阻塞性肺疾病
医院感染
危险因素
糖皮质激素
Chronic obstructive pulmonary diseases
Nosocomial infection
Risk factors
Glucocorticosteroid
作者简介
通讯作者：屠春林，E-mail：tuchunlin@yahoo．com．cn
