摘要
目的:测定辣椒碱在不同介质中的平衡溶解度。方法:采用HPLC测定辣椒碱在生理盐水、油酸、肉豆蔻酸异丙酯、不同体积分数乙醇、乙醇-磷酸盐缓冲液、聚乙二醇400水溶液中的溶解度。结果:随着所选用溶剂极性的降低,辣椒碱的溶解度逐渐增大;混合溶剂中半极性溶剂的比例增加,辣椒碱溶解度逐渐增大;当乙醇体积分数为40%时,辣椒碱的溶解度增加到30.4 g.L-1。结论:辣椒碱的平衡溶解度与介质的极性有关,可通过调节介质的极性,增加辣椒碱的溶解度。
Objective：To determine the equilibrium solubility of capsaicin in various medium.Method：To determine the solubility of capsaicin in physiological saline,oleic acid,isopropyl myristate,different concentration of ethanol,ethanol-phosphate buffer solution and polyethylene glycol 400 by HPLC.Result：The solubility of capsaicin increases with the decreasing polarity of solvent and the increasing percentage of semi-polarity solvent.When the concentration of ethanol was 40%,the solubility of capsaicin increased to 30.4 g·L-1.Conclusion：The equilibrium solubility of capsaicin depends on the polarity of the medium.We can regulate the polarity of the medium to increase the solubility of capsaicin.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第18期40-42,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
辣椒碱
平衡溶解度
油酸
肉豆蔻酸异丙酯
乙醇
介质
capsaicin
equilibrium solubility
oleic acid
isopropyl myristate
ethanol
medium
作者简介
李宏树，药师，硕士，从事药剂学研究，Tel：022-60578196
[通讯作者]张莉，教授，硕士，从事药物新剂型等研究，Tel：022-60578196，E-mail：zhli62tianjin@yahoo．com．cn
