摘要
目的:观察阿托伐他汀治疗冠心病合并高脂血症的临床疗效。方法:选取我院2008年6月-2010年9月213例确诊为冠心病合并高脂血症的患者为研究对象,随机分为治疗组(113例)和对照组(100例),2组均按冠心病伴高脂血症常规内科治疗,治疗组加用阿托伐他汀20mg,qd,口服。2组均8周为一疗程。治疗前后进行血、尿常规,血糖及肝、肾功能,心电图等指标检测,并对比其疗效。结果:治疗8周后,治疗组总胆固醇、甘油三酯、低密度脂蛋白、C反应蛋白、白细胞介素-6、肿瘤坏死因子-α、vonWill-ebrand因子、内皮素均较治疗前显著下降,高密度脂蛋白及一氧化氮均显著升高,治疗前后比较,差异有统计学意义(P<0.05),而对照组治疗前后上述指标比较无显著性差异(P>0.05);治疗组治疗后显效率及总有效率分别为77.0%和95.6%,与对照组(61.0%和76.0%)比较,差异有统计学意义(P<0.05)。结论:阿托伐他汀治疗冠心病合并高脂血症疗效确切,不良反应少。
OBJECTIVE：To observe the clinical efficacy of atorvastatin in the treatment of coronary heart disease（CHD） complicating with hyperlipidemia.METHODS：213 cases of CHD complicating with hyperlipidemia from Jun.2008 to Sept.2010 were randomly divided into treatment group（113 cases） and control group（100 cases）.Both groups were given conventional therapy for CHD complicating with hyperlipidemia.Treatment group was additionally treated with atorvastatin 20 mg,qd,p.o.for 8 weeks.A treatment course lasted for 8 weeks.The blood and urine routine,blood sugar,liver and renal function,electrocardiogram were detected and compared before and after treatment.RESULTS：After 8 weeks treatment,the levels of TC,TG,LDL-C,CRP,IL-6,TNF-α,vWF and ET in treatment group were lowered significantly while the levels of HDL-C and NO were increased after treatment.There was significant difference（P0.05）.Above index of control group had no significant difference before and after treatment（P0.05）.The obvious effective rate and total effective rate of control group were 77.0% and 95.6%,and those of control group were 61.0% and 76.0%,there was statistical significance（P0.05）.CONCLUSION：The treatment of CHD combined with hyperlipidemia by atorvastatin has obvious effect with less adverse drug reactions.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第36期3426-3428,共3页
China Pharmacy
关键词
阿托伐他汀
冠心病
高脂血症
Atorvastatin
Coronary heart disease
Hyperlipidemia
作者简介
副主任医师，本科。研究方向：高血压、冠心病的治疗。电话：0898—63231365。E—mail：shiqiu0898@163．com
