摘要
以碘为催化剂,苯甲醛与4-硝基苯乙酮经羟醛缩合反应合成了4-硝基查尔酮。考察了醛酮物质的量比、催化剂用量、反应时间和不同溶剂对4-硝基查尔酮收率的影响。结果表明,以乙醇为溶剂,在回流条件下,当4-硝基苯乙酮的用量为10 mmol,苯甲醛的用量为12 mmol,即酮醛物质的量比为1∶1.2,催化剂用量为6 mmol,反应3.0 h时,查尔酮收率可达到75.51%,且具有很高的纯度。
4-Nitrochalcone was prepared through the aldol condensation of benzaldehyde with 4-nitroaeeto- phenone using iodine as catalyst. The effects of the molar ratio of benzaldehyde to 4-nitroacetophenone, the amount of catalyst, reaction time and different solvents on the yield were discussed. The results showed that when the molar ratio of 4-nitroacetophenone（ 10 mmol）to benzaldehyde （12 mmol） was 1： 1.2,the amount of catalyst was 6 mmol and the reaction time was 3.0 h in ethanol under reflux, the yield of 4-ni- trochalcone reached 75.51%. The product obtained with high purity.
出处
《应用化工》
CAS
CSCD
2011年第8期1346-1347,1353,共3页
Applied Chemical Industry
基金
陕西省科技厅自然科学基金(2011JM2009)
陕西省重点实验室重点科学研究项目(2003JS018)
宝鸡文理学院重点项目(ZK1035)
作者简介
赵卫星（1979-），男，陕西咸阳人，宝鸡文理学院讲师，从事新型材料的制备和应用的研究。电话：15891203950，E-mail：weixingzhao@163．com
