摘要
目的探讨尿中阿尔茨海默病相关神经丝蛋白(AD7c-NTP)含量在阿尔茨海默病(AD)患者诊断和病情评估中的临床意义。方法采用酶免法(ELISA)检测223例老年人,其中AD组43例、早期AD组20例、血管性痴呆组(VD组)50例、智能正常老年对照组110例尿液中AD7c-NTP的含量,并进行统计分析。结果 AD组、早期AD组、VD组和正常老年对照组尿中AD7c-NTP含量分别为(4.61±2.49)、(4.32±2.60)、(1.21±0.68)和(1.10±0.46)ng/mL。AD组、早期AD组含量明显高于另外两组;而VD组与正常老年对照组差异无统计学意义(P>0.05);AD组内患者尿液中AD7c-NTP的含量与其痴呆程度呈正相关。结论检测尿液中AD7c-NTP含量作为无创性的检查,在AD诊断和病情评估中具有重要的临床参考价值。
Objective To explore the value of detection of urine AD7c-NTP assay in clinical diagnosis of Alzheimer＇s disease（AD）.Methods The urine AD7c-NTP level was determined using enzyme-linked immunosorbent assay in 223 senile persons divided into four groups ： the AD group（43cases）,the early AD group（20 cases）,the vascular dementia group（VD,50 cases） and the normal group（110 cases）.Statistical analysis was performed using SPSS 13.0.Results The urine AD7c-NTP content of the four groups were（4.61±2.49）ng/ml,（4.32±2.60）ng/ml,（1.21±0.68）ng/ml and（1.10±0.46）ng/ml.Compared with the normal group and the VD group,the levels of urine AD7c-NTP in AD group and early AD were significantly higher and positively correlated with the severity of the disease.Sgnificant difference was noticed between the VD group and the normal group.Conclusion The level of urine AD7c-NTP as a biochemical marker of AD,is of important and practical value in clinical diagnosis and assessment of AD.
出处
《中国热带医学》
CAS
2011年第8期993-994,共2页
China Tropical Medicine
基金
深圳市南山区科技局项目(No.2009005)
