摘要
目的探讨有氧运动康复对慢性心力衰竭(心衰)患者运动心排血量(co)及相关参数的影响。方法经心脏超声心动图检测后确定左室射血分数〈0.49的心衰患者50例,随机分为运动组及对照组各25例,并实施心肺运动试验。运动组执行以无氧代谢阈值(anaerobie threshold,AT)前10J/s为运动强度而制定的有氧运动处方;对照组要求日常活动。运动组先进行6次医院监护下的有氧运动训练,之后采用家庭有氧运动训练。3个月后复查两组心肺运动试验。结果两组患者静息CO、峰值c0(peakCO)、最大运动与静息状态c0差值(ACO)、心脏峰值功率输出(peak cardiacpower output,peakCPO)、静息心率(HR)、AT时HR(HRAT)、峰值运动时HR(HRpeak)、静息平均动脉压(MAP)、峰值运动时MAP(peakMAP)基线水平差异均无统计学意义[运动组与对照组比较分别为:(4.2±2.0)L/min比(3.3±1.0)L/min,(6.2±2.7)L/min比(5.2±1.8)L/min,(1.8±2.9)L/min比(2.0±1.8)L/min,(1.3±0.5)J/s比(1.2±0.5)J/s,(76.8±13.5)次/min比(73.4±11.9)次/min,(91.5±11.3)次/min比(92.6±12.4)次/min,(106.0±12.9)次/min比(108.3±17.4)次/min,(80.8±9.9)mmHg(1mmHg=0.133kPa)比(87.6±13.3)mmHg,(98.8±12.4)mmHg比(102.7±13.9)mmHg,均为P〉0.05]。3个月前的CO、peakCO、△CO、peakCPO、HR、HRAT、HRpeak、MAP、peakMAP的变化值在3个月后分别以△CO、△peakCO、△△CO、△peakCPO、△HR、△HRAT、△HRpeak、△MAP、△peakMAP表示;经过3个月有氧运动康复后,两组患者△CO、△peakCO、△△CO、△peakCPO、△HR、△HRAT、△HRpeak、△MAP、△peakMAP差异无统计学意义[运动组与对照组变化值比较分别为:(-0.7±2.4)L/min比(0.7±2.0)L/min,(1.1±2.6)L/min比(1.4±2.1)L/min,(0.1±3.7)L/min比(-0.2±2.5)L/min,(0.2±1.0)J/s比(0.2±0.5)J/s,(-0.4±7.6)次/min比(1.9±9.9)次/min,(3.4±11.3)次/min比(-2.8±7.6)次/min,(8.9±14.5)次/min比(3.7±14.4)次/min,(1.5±12.8)mmHg比(-1.3±11.1)mmHg,(6.4±18.9)mmHg比(1.3±12.3)mmHg,均为P〉0.05]。结论3个月的有氧运动康复未明显改善心衰患者的运动CO及相关参数。
Objective To observe the effects of aerobic exercise on cardiac output during exercise in patients with chronie heart failure (CHF). Methods A total of 50 CHF patients ( eehocardiography measured left ventricular ejection fraction 〈 0.49 ) were enrolled in the study and randomly divided into aerobic exercise group ( n = 25) and control group ( n = 25). Cardiopulmonary exercise testing (CPET) was performed. Patients of aerobic exercise group underwent aerobic exercise according to aerobic exercise prescription and exercise intensity is decided by anaerobic threshold before 10 J/s (1 minute before) of the oxygen consumption. After 6 supervised aerobic exercise training sessions in the hospital, patients were asked to perform the home-based aerobic exercise training. Patients in control group were required to maintain daily physical activities. CPET were reviewed 3 months later. Results Cardiac output(CO) ,peak CO, peak cardiac power output ( peak CPO), resting heart rate ( HR), heart rate at AT ( HR AT), HR peak, resting mean arterial pressure (MAP), peak MAP at baseline were similar between aerobic exercise group and control [ (4. 2 ±2. 0) L/rain vs. (3.3 ± 1.0) L/min, (6. 2 ±2. 7 ) L/min vs. (5.2 ± 1.8 ) L/min, ( 1.8 ± 2. 9 ) L/min vs. ( 2. 0 ± 1.8 ) L/min, ( 1.3 ± 0. 5 ) J/s vs. ( 1.2 ± 0. 5 ) J/s, ( 76. 8± 13.5 ) beats/rain vs. (73.4 ± 11.9 )beats/rain, (91.5 ± 11.3 )beats/rain vs. (92. 6 ±12.4 )heats/rain, (106. 0 ± 12. 9 ) beats/min vs. ( 108.3 ± 17.4 ) beats/rain, ( 80. 8 ± 9. 9 )mm Hg( 1 mm Hg = 0. 133 kPa) vs. ( 87.6 ± 13.3 ) mm Hg,(98. 8 ± 12.4)mm Hg vs. (102.7±13.9)ram Hg,all P 〉0.05]. Compared to baseline,CO,peak CO, peak CPO, HR, HR AT, HR peak, MAP, peak MAP after 3 months were similar between aerobic exercise group and control( all P 〉 0.05 ). The differences between baseline and 3 months later expressed as △CO, △peak CO, Apeak CPO, AHR, AHR AT, AHR peak, &MAP, Apeak MAP were also similar between aerobic exercise group and control group [ ( - 0. 7 ± 2. 4 ) L/rain vs. ( 0. 7 ± 2. 0 ) L/rain, ( 1.1 ± 2. 6 ) L/min vs. (1.4±2. 1)L/rain,(0. 1 ± 3.7) L/min vs. ( -0.2 ±2. 5) L/rain, (0. 2 ± 1.0) J/s vs. (0.2 ±0. 5)J/s, ( -0.4±7.6)beats/rain vs. (1.9 ± 9.9) beats/min, (3.4 ± 11.3) beats/rain vs. ( - 2.8 ± 7.6) beats/min, ( 8. 9 ±14. 5 ) beats/rain vs. ( 3.7± 14.4) beats/min, ( 1.5 ±12. 8 ) mm Hg vs. ( - 1.3± 11.1 ) mm Hg,(6. 4 ± 18.9)mm Hg vs. (1.3 ±12.3)mm Hg,al[ P 〉3.05]. Conclusion Three months aerobic exercise training did not improve cardiac output and related parameters during exercise in this cohort patients with CHF.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2011年第8期700-705,共6页
Chinese Journal of Cardiology
基金
上海市重大科技攻关基金(05DZ19505)
上海市市级医院新兴前沿技术联合攻关项目(SHDC12010117)
关键词
心力衰竭
充血性
心排血量
运动
Heart failure, congestive
Cardiac output
Exercise
作者简介
通信作者:王乐民,Email:wanglemin2003@163.com