摘要
[目的]研究纳米二氧化硅(nm-SiO2)对大鼠血清生化指标的影响。[方法]25只SPF级雄性SD大鼠,随机分为生理盐水对照组、微米级二氧化硅对照组、纳米低剂量组、纳米中剂量组、纳米高剂量组5组,鼻腔滴注染毒8周;随后采集血液,采用生化分析仪检测血清生化指标。[结果]nm-SiO2染毒组与对照组相比,天冬氨酸氨基转移酶(AST)水平显著降低(P<0.05),其余指标间差异均不显著(P>0.05)。[结论]SD雄性大鼠鼻腔滴注nm-SiO2对肝功能生化指标有一定的影响,但对肾功能生化指标的影响不明显。
[Objective]To explore the effects of silica nanoparticle（nm-SiO2） nasal instillation on serum biochemical indicators of rats.[Methods]25 SPF male SD rats were randomly divided into five groups,namely,control group of physiological saline,control group of μmSiO2,low-dosage group of μm-SiO2,middle-dosage group of μm-SiO2,high-dosage group of μm-SiO2.The rats were exposed to saline,nm-SiO2 or micro-sized SiO2 for 8 weeks.The blood of the rats were collected and analyzed by HITACHI 7080 Automatic Analyzer.[Results]Compared with the control group,AST levels were significantly lower in the serum of nm-SiO2-treated rats（P 0.05）,while the other indicators displayed no significant difference（P 0.05）.[Conclusion] These data indicated that nm-SiO2 nasal instillation had some effects on the biochemical indicators of liver function in a certain extent,while no significant effects on the biochemical indicators of renal function of the rats.
出处
《安徽农业科学》
CAS
北大核心
2011年第21期12922-12923,13113,共3页
Journal of Anhui Agricultural Sciences
基金
深圳市科技计划项目(201002098)
关键词
纳米二氧化硅
SD大鼠
血清
生化指标
Silica nanoparticle
SD rats
Serum
Biochemical indicators
作者简介
黄新凤（1971-），女，广东深圳人，主管技师，从事卫生检验及蛋白质组学方面的研究。
通讯作者
