摘要
目的评价还原型谷胱甘肽钠治疗小儿急性感染性疾病致肝功能损害的临床疗效。方法将肝损害患儿100例随机分为治疗组50例和对照组50例,治疗组给予还原型谷胱甘肽钠30mg/(kg.次)静脉滴注,1次/d;对照组给予维生素C100mg/(kg.次)及甘草酸二铵3mg/(kg.次)静脉滴注,1次/d。7d后复查肝功能。结果治疗后2组肝功能指标较治疗前显著降低(P<0.05),但治疗组ALT、AST较对照组下降更明显(P<0.05),且ALT、AST总有效率较对照组高(P<0.05)。结论还原型谷胱甘肽钠治疗小儿急性感染性疾病所致肝功能损害近期疗效显著、安全。
Objective To evaluate the clinical efficacy of reduced glutathion in the treatment of hepatic dysfunction caused by acute infectious diseases from childhood patients. Methods 100 childhood patients with hepatic dysfunction were divided randomly into treatment group （ 50 cases ） and control group （ 50 cases ）. Patients in treatment group were treated with reduced glutathion and those in control group were given vitamin C and Diammonium Glycyrrhizinate. Then the changes of hepatic dysfunctions were observed after 7 days. Results The levels of ALT, AST and r-GT were markedly reduced after treatment in the two groups （ P 〈 0.05 ）. But the levels of ALT and AST were much lower and the total rates of ALT and AST were higher in treatment group than control group （ P 〈 0.05 ）. Conclusion Reduced glutathion is effective and safe in the treatment of acute infectious diseases-induced hepatic dysfunction.
出处
《中国现代医生》
2011年第22期53-54,共2页
China Modern Doctor
关键词
小儿急性感染性疾病
肝功能损害
还原型谷胱甘肽
Acute infectious diseases from childhood patients
Hepatic dysfunction
Reduced glutathion
