摘要
目的观察瓣膜修复术治疗感染性心内膜炎的临床疗效。方法回顾性分析64例感染性心内膜炎患者的资料,常规血培养,采用K-B纸片法进行药敏试验,行瓣膜修复术。结果血培养阳性28例,阳性率为43.8%,主要为链球菌,占60.7%,金黄色葡萄球菌和表皮葡萄球菌各占14.3%;革兰阳性菌对常用抗菌药物耐药性非常高,对万古霉素、利奈唑胺和替考拉宁耐药率低;25例获得随访,随访时间2~36个月,平均（19.6±7.3）个月,死亡率为7.1%;NYHA分级由术前的（2.7±0.6）级恢复至（1.5±0.8）级。结论瓣膜修复术治疗感染性心内膜炎对于维持心脏结构整体性和术后心功能恢复具有重要意义,对于择期手术患者应根据细菌培养和药敏结果选择合适的抗菌药物治疗。
OBJECTIVE To investigate the clinical effect of valvuloplasty on infective endocarditis（IE）.METHODS The data of 64 cases with IE were reviewed.The blood was analyzed by routine culture method,and the antimicrobial susceptibility was tested by K-B paper disk method.All the cases were treated with valvuloplasty.RESULTS Totally 28 cases（43.8%） showed positive results by blood culture,and the main pathogens were Streptococcus（60.7%）,Staphylococcus aureus（14.3%）,and Staphylococcus epidermidis（14.3%）.The Gram-positive bacteria showed high durg resistance to normal drugs,but lower to vancomycin,linezolid,and teicoplanin.25 cases（89.3%） were followed up for 2~36 months（AVG： 19.6±7.3 months）.2 cases（7.1%） died.NYHA classfication was decreased from（2.7±0.6） to（1.5±0.8）.CONCLUSIONS Valvuloplasty is a effective surgical method for cardiac structure integrity and postoperative heart function recovery.The bacteria culture and drug sensitive detection are necessary to elective surgery.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第16期3366-3368,共3页
Chinese Journal of Nosocomiology
关键词
瓣膜修复术
感染性心内膜炎
药敏
Valvuloplasty
Infective endocarditis
Drug sensitivity
