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2型糖尿病大血管病变患者可溶性血管细胞黏附分子-1变化的临床意义 被引量：2

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摘要 目的探讨2型糖尿病(T2DM)大血管病变患者血清可溶性血管细胞黏附分子-1(sVCAM-1)变化的临床意义。方法选择40例T2DM患者,按有无大血管病变分两个亚组;另选非DM合并大血管病变患者20例、体检健康者20例作对照。采用双抗夹心ELISA法检测各组血清sVCAM-1,并检测其餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)。结果 T2DM患者sVCAM-1明显高于对照者,T2DM合并大血管病变者高于无大血管病变者(P<0.01或<0.05);T2DM患者的sVCAM-1与2 h PG、HbA1c呈正相关(r分别为0.360、0.492,P均<0.05)。结论 VCAM-1可能参与T2DM大血管病变的发生、发展,血清sVCAM-1检测可作为T2DM大血管病变早期预测和病情评估的指标之一。
作者 董利平 李晓红 陈丽
机构地区 青岛市立医院 山东大学齐鲁医院
出处 《山东医药》 CAS 北大核心 2011年第25期53-54,共2页 Shandong Medical Journal
关键词 糖尿病 2型 大血管病变 可溶性血管细胞黏附分子-1
分类号 R587.1 [医药卫生—内分泌]
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参考文献5

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同被引文献24

  • 1Tecilazich F,Dinh T,Lyons TE. Postexercise phosphocreatine recovery,an index of mitochondrial oxidative phosphorylation,is reduced in diabetic patients with lower extremity complications[J].Journal of Vascular Surgery,2013,(4):997-1005.
  • 2Oh TS,Lee HS,Hong JP. Diabetic foot reconstruction using free flaps increases 5-year-survival rate[J].JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY JPRAS,2013,(2):243-250.
  • 3Faglia E,Clerici G,Airoldi F. Revascularization by angioplasty of type D femoropopliteal and long infrapopliteal lesion in diabetic patients with critical limb ischemia:are TASC Ⅱ recommendations suitable? A population-based cohort study[J].Int J Low Extrem Wounds,2012,(4):277-285.
  • 4Dziemidok P,Szczesniak G,Kostrzewa-Zablocka E. Is the advancement of diabetic angiopathy evaluated as ankle-brachial index directly associated with current glycaemic control[J].Annals of Agricultural and Environmental Medicine,2012,(3):563-596.
  • 5Jablecka A,Bogdafiski P,Balcer N. The effect of oral L-arginine supplementation on fasting glucose,HbAlc,nitric oxide and total antioxidant status in diabetic patients with atherosclerotic peripheral arterial disease of lower extremities[J].European Review for Medical and Pharmacological Science,2012,(3):342-350.
  • 6Hermans MP. Non-invited review:prevention ofmicrovascular diabetic complications by fenofibrate:lessons from FIELD and ACCORD[J].Diab Vasc Dis Res,2011,(3):180-189.
  • 7Sixt S,Scheinert D,Rastan A. One-year outcome after percutaneous rotational and aspiration atherectomy in infrainguinal arteries in patient with and without type 2 diabetes mellitus[J].Annals of Vascular Surgery,2011,(4):520-529.
  • 8Tuttle LJ,Sinacore DR,Cade WT. Lower physical activity is associated with higher intermuscular adipose tissue in people with type 2 diabetes and peripheral neuropathy[J].Physical Therapy,2011,(6):923-930.
  • 9Edmundsson D,Toolanen G. Chronic exertional compartment syndrome in diabetes mellitus[J].Diabetic Medicine,2011,(1):81-85.
  • 10Orrico C,Pasquinelli G,Foroni L. Dysfunctional vasa vasoum in diabetic peripheral artery obstructive disease with critical lower limb ischaemia[J].European Journal of vascular and endovascular surgery,2010,(3):365-374.

引证文献2

二级引证文献11

山东医药
2011年 第25期

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