摘要
Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models. However, none recapitulates all of the characteristics of human colorectal cancer. It is critical to use a specific mouse model to address a particular research question. Here, we review commonly used mouse models for human colorectal cancer.
Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models. However, none recapitulates all of the characteristics of human colorectal cancer. It is critical to use a specific mouse model to address a particular research question. Here, we review commonly used mouse models for human colorectal cancer.
基金
sponsored by the NIH/NCI grant K99CA138914 (YT), CA112081 (WY), R01CA02603831
an A*STAR Investigator Grant (HPK)
作者简介
Corresponding Author. Yunguang Tong, Davis Building, Room 2015 8700 Beverly Blvd, Los Angeles, CA 90048, USA. Tel： ＋1-310-423-7669; Fax： ＋1-310-423-0221; Email： tongy@cshs.org.
