摘要
目的观察大剂量的厄贝沙坦对糖尿病肾病(DN)患者疗效的影响。方法糖尿病肾病(DN)患者50例,随机(信封发)分为治疗组(大剂量厄贝沙坦组)以及对照组(小剂量厄贝沙坦组),4周后比较治疗效果及药物不良反应。结果两组患者血压都有降低,但两组差异无统计学意义(P>0.05),尿清蛋白均显著下降(Pa<0.01,Pb<0.05),大剂量组治疗后尿清蛋白下降更为显著,其效果优于小剂量组(P<0.05)。结论大剂量厄贝沙坦的应用对DN患者有独立于血压之外的肾脏保护作用,安全性好。
Objective To observe the High-dose Irbesartan treatment diabetic nephropathy（DN） patients the effect of adenoidectomy.Methods Diabetic nephropathy（DN） patients 50 cases（envelope hair）,randomly divided into the treatment group（high-dose Irbesartan group,n=25） and control group（small doses of Irbesartan group,n=25）,4 weeks after comparing therapeutic effect and medication side-effects.Results Two groups of patients had lower blood pressure,but the two groups difference was statistically significant（P0.05）,urinary albumin were significantly decrease（Pa0.01,Pb0.05）,high-dose Irbesartan groups after treating urinary albumin decline,the effect is more significant than small dose group（P0.05）.Conclusion High-dose Irbesartan application on the DN patients have independent of blood pressure outside of the renal protection effect,good safety.
出处
《四川医学》
CAS
2011年第7期1081-1082,共2页
Sichuan Medical Journal
