摘要
目的分析临床标本中念珠菌属的菌种分布及对常用抗真菌药物的敏感性,为临床合理用药提供依据。方法总结分析昆明市延安医院2005—2009年念珠菌属的菌种分布及其对5种常用抗真菌药物的敏感性。药敏试验采用ATB-Fungus-3微量稀释法。结果在2005—2009年分离的共143株念珠菌中,白念珠菌占39.2%(56/143),非白念珠菌占60.8%(87/143),非白念珠菌中,以光滑念珠菌24.5%(35/143)、热带念珠菌7.7%(11/143)和近平滑念珠菌5.6%(8/143)较为常见。143株念珠菌对氟胞嘧啶、两性霉素B、氟康唑、伊曲康唑和伏立康唑的总敏感率分别为86.0%、100%、90.9%、69.9%和93.5%,56株白念珠菌对上述5种抗真菌药的敏感率分别为91.1%、100%、96.4%、82.1%和96.3%,87株非白念珠菌的敏感率分别为82.8%、100%、87.4%、62.1%和92.0%。结论白念珠菌仍是目前念珠菌感染较常见的菌种,但非白念珠菌已显著增加;白念珠菌对常用抗真菌药仍有较高的敏感性,非白念珠菌的耐药性则高于白念珠菌。临床在治疗念珠菌感染时应结合菌种鉴定及药敏试验结果合理选择抗真菌药物。
Objective To analyze the species distribution and antifungal susceptibility of 143 Candida strains isolated from clinical specimens.Methods A comprehensive study was carried out to analyze the species distribution of Candida spp.and their susceptibility to five commonly used antifungal agents.A total of 143 isolates were collected from Yan＇an Hospital between 2005 and 2009.Antifungal susceptibility testing was conducted with ATB-Fungus-3 strip.Results Candida albicans accounted for 39.2%（56/143）,and non-albicans Candida spp.60.8%（87/143）,including Candida glabrata 24.5%（35/143）,Candida tropicalis 7.7%（11/143） and Candida parapsilosis 5.6%（8/143）.Of the 143 Candida isolates,the overall percentage of strains susceptible to flucytosine,amphotericin B,fluconazole,itraconazole,and voriconazole was 86.0%,100%,90.9%,69.9%,and 93.5%,respectively.About 91.1%,100%,96.4%,82.1%,and 96.3% of the 56 Candida albicans strains were susceptible to these five antifungal agents.Of the 87 non-albicans Candida spp.isolates,the susceptibility rates were 82.8%,100%,87.4%,62.1%,and 92.0%,respectively.Conclusions Candida albicans remains a common species in Candida infections.Non-albicans Candida spp.is also increasing.Candida albicans isolates are still highly susceptible to the common antifungal agents.Non-albicans Candida species are more resistant than Candida albicans.Clinical antifungal therapy should be based on the results of pathogen identification and antifungal susceptibility testing.
出处
《中国感染与化疗杂志》
CAS
2011年第4期303-305,共3页
Chinese Journal of Infection and Chemotherapy
关键词
念珠菌
抗真菌药
敏感性
Candida
antifungal agent
antifungal susceptibility
作者简介
黄云昆（1966-），男，副主任检验师，主要从事临床微生物学检验专业。通信作者：黄云昆，E-mail：huangyunkun@hotmail．com。
