摘要
目的建立人工牛黄甲硝唑胶囊中甲硝唑溶出度的测定方法。方法采用紫外分光光度法,检测波长为277 nm,测定人工牛黄甲硝唑胶囊中甲硝唑的体外溶出度。结果甲硝唑的质量浓度在4.22～20.10μg/mL范围内与吸光度呈良好的线性关系(r=0.999 8),平均回收率为99.00%,RSD为0.55%(n=6)。结论该方法操作简便、结果准确、重现性好,可用于人工牛黄甲硝唑胶囊中甲硝唑溶出度的测定。
Objective To establish the determination method of the dissolution rate of metronidazole in Galculus Bovis and Metronidazole Capsules.Methods The UV spectrophotoretric method was adopted for detection of dissolution rate at the wavelength 277 nm.Results The linear range of metronidazole was 4.22-20.10 μg/mL（r=0.999 8）.The average recovery rate of metronidazole was 99.00%,RSD=0.55%（n=6）.Conclusion The method is simple,rapid and accurate with good reproducibility,which can meet the demand determining the dissolution rate of metronidazole in Galculus Bovis and Metronidazole Capsules.
出处
《中国药业》
CAS
2011年第14期34-35,共2页
China Pharmaceuticals
关键词
人工牛黄甲硝唑胶囊
溶出度
测定
galculus bovis and metronidazole capsules
dissolution rate
determination
作者简介
韦广辉（1968-），男，本科，工程师，（电话）0771-5855031（电子信箱）Weigh@gxfda．gov．cn。
