摘要
我国胃食管反流病(GERD)发病率逐年升高.GERD可能引起反流性食管炎、慢性咳嗽、哮喘、Barrett's食管和食管腺癌等并发症,并且严重影响人们的生活质量.质子泵抑制剂(PPIs)的应用,使多数患者症状得到了缓解.但近年来发现PPIs对部分GERD患者无效,且长期使用会出现间质性肾炎、骨折和小肠细菌增生过多等并发症.近年来,一些新型药物逐渐应用于临床.本文就GERD药物治疗进展作一综述.
The incidence of gastroesophageal reflux disease （GERD） is increasing drastically in China. GERD could probably cause reflux esophagitis, chronic cough, asthma, Barrett’s esophagus and adenocarcinoma, and frequently affects health-related quality of life. The use of proton pump inhibitors （PPIs） provides effective symptomatic relief in most patients; however, some patients appear refractory to the treatment with PPIs. The long term use of PPIs might also cause adverse effects, such as interstitial nephritis, fracture and small intestinal bacterial overgrowth. Many new drugs for GERD have emerged recently. This article reviews the advances in drug therapy for GERD.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第16期1711-1719,共9页
World Chinese Journal of Digestology
基金
江西省卫生厅重大招标基金资助项目
No.20104002~~
关键词
胃食管反流病
药物
治疗
Gastroesophageal reflux disease
Drug
Therapy
作者简介
通讯作者：朱萱，教授，主住医师，330006，江西省南昌市，南昌大学第一附属医院消化内科．jyyfyzx@163．com
