摘要
目的探讨复方苦参注射液对直肠癌患者肿瘤标志物CEA、CA199及生活质量的影响。方法将58例直肠癌患者随机分成两组,治疗组29例应用FOLFOX-4方案加复方苦参注射液静脉滴注,对照组29例应用FOLFOX-4方案。比较直肠癌患者使用复方苦参注射液前后CEA、CA199检测值及生活质量评分的变化。结果治疗组优于对照组,治疗组在化疗结束后第12天CEA为(4.23±0.50)ng/L,CA199为(18.11±3.14)ng/ml,均低于化疗结束后第一天CEA(5.34±0.48)ng/L,CA199(26.31±2.36)ng/L,但两者差异无显著性(P>0.05);对照组在化疗结束后第1天和第12天CEA和CA199的值变化不大,差异亦无显著性。治疗组Karnofsky降低率(17.2%)明显低于对照组(48.3%),两者差异有显著性(P<0.05)。结论复方苦参注射液可降低直肠癌康复期患者CEA及CA199水平,但差异无显著性。复方苦参注射液治疗能提高KPS得分,有效改善生存质量,差异有显著性。
Objective To study the effect of Yan-shu Injection on tumor markers（CEA,CA199）and quality of life in rectal cancer patients.Methods A total of 58 patients with rectal cancer were enrolled,29 were randomized to treatment group（chemotherapy plus Yan-shu） and 29 to control group（chemotherapy）.The regimen of FOLFOX-4 was taken for chemotherapy.The variation of tumor markers（CEA,CA199） in peripheral blood and quality of life before and after therapy with Yan-shu Injection were observed.Results The levels of CEA（4.23±0.50ng/L） and CA199（18.11±3.14ng/L） on the 12th day were lower than those on the 1st day after chemotherapy,but there was no significant difference（P0.05）.Meanwhile,there was also no difference in control group.The lowering rate of KPS score in treatment group（17.2%） was significantly lower than that of control group（48.3%）（P0.05）.Conclusion The application of Yan-shu Injection can reduce the level of tumor markers（CEA,CA199） in rectal cancer patients,and increase KPS score,thus improving the quality of life efficiently.
出处
《中国肿瘤临床与康复》
2011年第3期285-286,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
作者简介
王奕，男，副主任药师，学士，从事药品管理、临床药学专业。
