摘要
采用乳化-溶剂挥发法,以头孢噻肟钠(CTX)为模型药物,以自制两亲性聚合物淀粉聚乳酸接枝共聚物(ST-g-PLA)为药物载体,制备了CTX/ST-g-PLA载药微球。考察了乳化剂PVA浓度、油水体积比、ST-g-PLA浓度及搅拌速度对微球粒径、载药量及包裹率的影响,采用IR,DSC和SEM等技术对微球结构进行了表征,研究了微球在4种不同介质中的降解性及体外释药性能。结果表明,当PVA浓度为2%,Vo/Vw=1∶6,共聚物浓度为30%时,制备的微球外型规则,分散性好,载药率为8.2%,包载率为49.2%;微球在不同环境中降解速率不同:肠液>碱液>PBS>酸液;较PLA微球,CTX/ST-g-PLA微球有良好的缓释性。
Microspheres containing drug were prepared by oil-in-water emulsification-solvent evaporation technique,with the self-made amphiphilic and biodegradable polymer,starch graft poly（lactic acid）（ST-g-PLA） as the carrier,and cefotaxime as the model drug.The effect of PVA,oil/water vacuum ratio（Vo/Vw）,polymer concentration in organic solvent,and stirring speed on diameter of microsphere,drug loading and ecapsulation efficiency were discussed.The microspheres were characterized by IR,DSC and SEM.The degradation ability of the microspheres in four surroundings was examined,and the drug release in vitro was evaluated.The results showed that when concentration of PVA and ST-g-PLA were 2% and 30%,respectively,Vo/Vw was 1∶6,the prepared microspheres had spherical shape with uniformity size and good dispersion.The drug loading rate and encapsulation efficiency were 8.2% and 49.2%,respectively.The degradation rate of microspheres were： artificial intestinal liquidalkali liquidPBSacid liquid,and the sustained release was remarkable.
出处
《应用化工》
CAS
CSCD
2011年第6期964-968,共5页
Applied Chemical Industry
基金
陕西省自然科学基金项目(08JK482)
作者简介
杨小玲（1976-），女，陕西西安人，咸阳师范学院工程师，硕士，从事天然高分子改性研究。电话：13891088503，E—mail：yangxl28@163．com
