摘要
目的探讨腹型肥胖脑血栓患者是否存在阿司匹林抵抗及其原因。方法选择病情稳定的脑血栓患者125例，根据腰围分为腹型肥胖组和非腹型肥胖组，测定两组的血小板聚集率、TNF-a、IL-6和C反应蛋白。Logistic多元回归分析用于评价阿司匹林抵抗和各种危险因素的联系程度。结果腹型肥胖组阿司匹林抵抗的发生率、TNF-a、IL-6和C反应蛋白均明显高于非腹型肥胖组（P〈0．05），年龄、TNF—a、IL-6和C反应蛋白是脑血栓患者发生阿司匹林抵抗的独立危险因素。结论腹型肥胖脑血栓患者易发生阿司匹林抵抗，可能与患者体内的炎症介质增加有关，临床工作中要高度重视该类患者。
Objective To investigate if aspirin resistance exists in cerebral thrombosis patients with abdominal obesity and the reasons for it. Methods 125 subjects with stable cerebral thrombosis disease were included as research objects,all the subjects were divided into two groups according to waist circumference：abdominal obesity group and non-abdominal obesity group. Platelet aggregation rate, serum levels of TNF-a, IL-6 and C-reactive protein （CRP） were measured in both groups. Multivariate logistic regression analysis was used to estimate the strength of association between aspirin resistance and various factors. Results Compared with non-abdominal obesity group, platelet aggregation rate and the levels of TNF-a, IL- 6 and CRP were significantly higher in abdominal obesity group （P 〈 0.05 ）. Age, TNF-a, IL-6 and CRP were independent risk factors for aspirin resistance. Conclusions Aspirin resistance exists in cerebral thrombosis patients with abdominal obesity, and it is associated with higher levels of inflammatory factors. This kind of patients must be paid close attention in clinical practice.
出处
《临床内科杂志》
CAS
2011年第6期384-386,共3页
Journal of Clinical Internal Medicine
关键词
脑血栓
阿司匹林抵抗
腹型肥胖
炎症因子
Cerebral thrombosis
Aspirin resistance
Abdominal obesity
Inflammatory factors
