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慢性牙周炎对类风湿性关节炎患者血清中IL-18的影响 被引量:3

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摘要 目的慢性牙周炎与类风湿性关节炎之间的联系问题已经引起了更多关注。通过对类风湿性关节炎合并慢性牙周炎,类风湿性关节炎和健康对照人群血清白细胞介素-18(IL-18)的检测和分析,初步探讨慢性牙周炎和类风湿性关节炎的关系。方法按纳入标准选择20名慢性牙周炎合并类风湿性关节炎患者作为一组,20名类风湿性关节炎作为一组;20名健康人群作为对照组,记录探诊出血指数(BOP)、牙周袋探诊深度(PD)和临床附着丧失(CAL)情况;收集静脉血清样本,采用酶联免疫吸附实验(enzyme-linked immunosorbent assay)法测定血清IL-18水平。结果类风湿性关节炎并慢性牙周炎组组血清IL-18平均浓度为(412.16±92.61)pg/mL,类风湿性关节炎组为(314.17±56.59)pg/mL,健康对照组(62.20±34.58)。类风湿性关节炎并慢性牙周炎组血清IL-18水平显著高于类风湿性关节炎组(P<0.001)两组血清IL-18水平均显著高于健康对照组(P<0.001)。结论慢性牙周炎对类风湿性关节炎中IL-18有影响。
作者 邓莉 刘辉
出处 《中国医药指南》 2011年第18期251-252,共2页 Guide of China Medicine
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参考文献8

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二级参考文献8

共引文献29

同被引文献42

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