摘要
目的探讨3．0TMR双反转恢复（DIR）序列在海马硬化（HS）诊断中的价值，分析DIR显示HS患者海马信号强度升高的能力。方法回顾性分析12例单侧HS患者和12名健康志愿者的临床和影像资料，所有受试者均采用3．0TMR行斜冠状面DIR、液体衰减反转恢复（FLAIR）序列和快速自旋回波（TSE）序列检查；分别在病变侧与对侧海马结构设置ROI，计算病变侧、对侧及正常对照组海马的相对信号强度，以及病灶的信噪比（SNR）、对比噪声比（CNR）、信号强度比（RSI）和不对称指数（AI），比较3种序列之间各评价指标有无差异。统计学处理采用单因素方差分析。结果病侧海马于DIR上呈极高信号，病变侧、对侧及正常对照组海马相对信号强度分别为1．50±0．05、1．26±4-0．03、1．18±0．05，3者间差异有统计学意义（F=172．609，P=0．000）。DIR、FLAIR、T2 TSE序列上的病侧海马SNR分别为84．13±16．62、50．904±12．38、63．254±15．46，3者间差异有统计学意义（F=15．185，P=0．000）；海马CNR分别为13．72±3．73、6．67±3．02、7．33±3．65，3者间差异有统计学意义（F=14．985，P=0．000）；3种序列之间两侧海马的R。AI差异均无统计学意义（P值均为0．078）。结论HS于DIR序列上呈特征性的极高信号，DIR图像显示HS的SNR和CNR优于常规MRI序列．其对HS的诊断具有一定价值。
Objective To investigate the imaging feature of hippoeampal sclerosis （HS）, and evaluate the diagnostic value of double inversion recovery （DIR） sequence at 3.0 T MR for its diagnosis. Methods Twelve patients with unilateral HS proven by pathology and 12 healthy volunteers were enrolled. All patients received DIR, fluid attenuated inversion recovery （ FLAIR ） and T2 TSE sequences scans on oblique coronal plane vertical to the hippocampal axis on a 3.0 T MR scanner. Regions of interest （ ROI ） were set respectively in ipsilateral and contralateral hippocampi hippocampi in patients with HS, and the bilateral hippocampi in healthy volunteneers were placed respectively. Signal to noise ratio （SNR） , contrast to noise ratio （ CNR ） , ratio of signal intensity （ Rsl ） and asymmetry index （ AI ） of each ROI in all hippocampi were calculated and compared among the three sequences. Statistical analysis was performed with one-way ANOVA. Results On DIR images, ipsilateral hippocampal lesions demonstrated extremely high signal intensity. Relative signal intensity of ipsilateral hippocampal lesions, eontralateral hippocampl and the hippocampi in control groups healthy volunteneers were 1.50 ± 0. 05, 1.26±0. 03, 1. 18 ± 0. 05 （ F = 172. 609,P = 0. 000）, respectively. SNR of ipsilateral hippoeampal lesions on DIR, FLAIR and T2 TSE sequences were 84. 13 ± 16. 62, 50. 90± 12. 38, 63.25 ± 15.46 （ F = 15. 185 ,P ：0. 000）, respectively. CNR of hippocampus were 13.72 ± 3.73, 6. 67 ± 3.02, 7. 33±3.65 （F = 14. 985, P = 0.000）, respectively. In HS patients, Rs, and AI of the ipsilateral hippoeampal lesions and contralateral hippocampi among the three sequences did not show statistically significant difference （P = 0. 078）. Conclusions HS manifests extremely high signal intensity on DIR images. On DIR images, the SNR and CNR of HS were higher than those on conventional MR sequences which provide valuable information for the diagnosis of HS.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2011年第6期543-546,共4页
Chinese Journal of Radiology
关键词
海马硬化
磁共振成像
双反转恢复
Hippocampal sclerosis
Magnetic resonance imaging
Double inversion recovery
作者简介
通信作者：张云亭，Email：cjr．zhangyunting@vip．163．com
