摘要
目的:探讨前列地尔联合缬沙坦治疗糖尿病肾病的临床效果。方法:将2007年1月至2010年12月期间收治的84例糖尿病肾病患者,随机分为三组,前列地尔组在综合治疗的基础上给予前列地尔静滴治疗;缬沙坦组在综合治疗的基础上给予缬沙坦口服治疗;观察组在综合治疗基础上给予前列地尔静滴加缬沙坦口服治疗;观察治疗前后三组患者的24h尿微量白蛋白、血压等指标的改善情况。结果:三组患者治疗后24h尿微量白蛋白均下降(P<0.01),血糖水平控制较理想,均达到或接近理想水平,血压54.8%达到正常水平,29.8%接近正常,15.5%未达标。另外联合治疗组的疗效优于前列地尔组和缬沙坦组,结果具有统计学意义。结论:前列地尔和缬沙坦具有降低蛋白尿、保护肾脏功能的作用,将两者联合应用可提高疗效,延缓病情发展,是治疗糖尿病肾病的一种有效的方法。
Objective：To study alprostadil combined with valsartan in treatment of diabetic nephropathy.Method：Randomly divided 84 diabetic nephropathy patients into three groups during January 2007 to December 2010,alprostadil group was given alprostadil infusion therapy on the basis of the comprehensive treatment;valsartan group in the consolidated valsartan treatment on the basis of oral treatment;the observation group was given combined therapy with alprostadil on the basis of intravenous plus oral treatment of Valsartan;Observed three groups of patients before and after treatment 24h urinary albumin,blood pressure and other indicators of improvement.Result：After treatment,three groups of patients were decreased 24h urinary albumin（P 〈0.01）,better control of blood glucose levels were at or close to the ideal level of blood pressure to normal levels of 54.8%,29.8% nearly normal,15.5% were not reached.Another combination therapy was more effective than alprostadil group and valsartan group,the results were statistically significant.Conclusion：Alprostadil and valsartan can reduce proteinuria and protect renal function in the role of the two in combination can improve efficacy,delay the progression of the disease,treatment of diabetic nephropathy is an effective method.
出处
《河北医学》
CAS
2011年第6期757-759,共3页
Hebei Medicine
关键词
糖尿病肾病
前列地尔
缬沙坦
Diabetic nephropathy
Alprostadil
Valsartan
