摘要
目的:探讨2型糖尿病患者血清内皮素(ET)、抵抗素水平与周围神经病变(DPN)的关系。方法:选择郑州大学第二附属医院内分泌科住院的2型糖尿病患者60例,经神经电生理检查分为单纯糖尿病组20例和DPN组40例,并选择健康体检者30例为对照组。采用放射免疫法和酶联免疫法测定各组血清ET、抵抗素水平。结果:单纯糖尿病组和DPN组血清ET、抵抗素水平均显著高于对照组(P<0.05),而DPN组ET、抵抗素水平显著高于单纯糖尿病组(P<0.05)。直线相关分析发现,2型糖尿病患者血清抵抗素水平与ET呈正相关(r=0.436,P<0.01)。Logistic回归分析发现病程、HbA1c、血清ET和抵抗素水平是与DPN发生相关的独立危险因素。结论:2型糖尿病患者血清ET、抵抗素水平与DPN密切相关;患者血清ET、抵抗素水平异常增高是可能导致DPN发生的危险因素。
AIM： To study patients with type 2 diabetes,endothelin（ET）,resistin level and peripheral neuropathy（DPN） relationship.METHODS： Second affiliated hospital of Zhengzhou university,department of endocrinology hospital of 60 patients with type 2 diabetes,the nerve electrophysiological examination of 20 cases were divided into DM group and 40 patients with DPN,and select the healthy control group of 30 cases.Radioimmunoassay and enzyme-linked immunosorbent assay of serum ET,resistin levels.RESULTS： The DM group and the DPN serum ET,resistin levels were significantly higher（P0.05）,while the DPN group ET,resistin levels were significantly higher than that of DM group（P0.05）.Linear correlation analysis showed that patients with type 2 diabetes serum resistin levels were positively correlated with ET（r=0.436,P0.01）.Logistic regression analysis showed that duration,HbA1c,serum resistin level in ET and be associated with DPN are independent risk factors.CONCLUSION： Patients with type 2 diabetes ET,resistin levels are closely related with the DPN;patients with ET,is the abnormal increase of resistin levels may lead to the risk factors of DPN.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2011年第5期564-565,567,共3页
Chinese Journal of Cellular and Molecular Immunology
关键词
2型糖尿病
周围神经病变
内皮素
抵抗素
type 2 diabetes mellitus
diabetic neuropathy
endothelin-1
resistin
作者简介
王莉梅（1977-），女，河南洛阳人，主治医师，博士Tel：0371-66912341；E—mail：lylimeiwang@live．cn。
Corresponding author
