摘要
采用热重(TG)和差示扫描量热(DSC)法测定了甲磺酸帕珠沙星(PZFX)在氮气氛和空气氛中的热分解过程,测定了PZFX及其在热分解过程中不同阶段残余物的红外光谱,运用量子化学GAMESS软件计算了PZFX分子的键级,推断了PZFX的热分解机理。结果表明PZFX的热分解过程的起始步骤是甲磺酸的分解。采用Ozawa方法计算得到PZFX热分解过程的表观活化能Ea和指前因子A,在5%失重的热分解初始阶段,在氮气氛中Ea为192.8kJ.mol-1,A为1.122×1017 min-1;在空气气氛中Ea为201.3kJ.mol-1,A为8.128×1017 min-1。PZFX在空气中常温下具有很好的热稳定性。
The thermal decomposition of pazufloxacin mesilate（PZFX） was measured by thermogravimetry（TG） and differential scanning colarimetry（DSC）,the IR spectra of PZFX and its remains in thermal decomposition at various temperatures were determined,the molecular bond orders were calculated by GAMESS method of quantum chemistry,and the mechanism of the thermal decomposition of PZFX has been discussed.The results indicated that the mesilate acid disintegration occurred in the initial step of the decomposition.The parameters of thermal decomposition kinetics,such as activation energy Ea and pre-exponential factor A,were obtained by using Ozawa method.At the initial stage with weight loss 5%,Ea and A were 192.8 kJ·mol-1 and 1.122×1017 min-1 respectively,in nitrogen atmosphere;Ea and A were 201.3 kJ·mol-1 and 8.128×1017 min-1 respectively,in air atmosphere.The prospective lifetime of PZFX at different temperature was speculated by Dakin equation.The thermal property of PZFX was quite stable in the ambient temperature.
出处
《分析科学学报》
CAS
CSCD
北大核心
2011年第3期297-301,共5页
Journal of Analytical Science
关键词
甲磺酸帕珠沙星
量子化学
热分析
机理
热重法
差示扫描量热法
Pazufloxacin mesilate
Quantum chemistry
Thermal analysis
Mechanism
Thermogravimetry
Differential scanning colarimetry
作者简介
通讯作者：王学杰，男，博士，教授，研究方向为药物分析．
