摘要
目的 观察卡培他滨单药治疗老年人恶性肿瘤的临床疗效及不良反应.方法 回顾性分析采用卡培他滨治疗的28例老年恶性肿瘤患者的临床资料,以WHO关于疗效评价标准和实体瘤疗效新标准（RECIST）评估治疗效果,分为完全缓解、部分缓解、稳定、进展,并观察药物不良反应发生情况.结果 28例患者均完成2个周期治疗后,完全缓解0例,部分缓解11例,稳定6例,进展11例,治疗总有效率60.7%;不良反应：消化道反应11例（39.3%）、骨髓抑制7例（25.0%）、口角炎10例（35.7%）、手足综合征6例（21.4%）.结论 卡培他滨对于老年人恶性肿瘤治疗效果良好,且耐受性好.
Objective To research the therapeutic effect and toxicity of capecitabine in elderly malignant tumor patients.Methods The data of 28 elderly malignant tumor patients were retrospectively analyzed,and RECIST standard was used to evaluate therapeutic effect as CR、PR、SD and PD.In the same time,the toxicity of capecitabine was observed.Results 28 elderly malignant tumor patients who have been treated by capecitabine were completed 2cycles therapy.The effective percentage ofthese patients Was 60.7%（CR 0 pemon,PR 11 persons,SD 6 persons,PD 11 persons）.The toxicity and side effect was controlled.Incidence of vomit Was 39.3%（11 persons）,marrow inhibition was 25%（7 persons）,angular stomatitis was 35.7%（10 persons）,and hand-foot syndrome Was 21.4%（6 persons）.Conclusion The therapeutic effect of capecitabine in elderly malignant tumor patients Was favourable,and the tolerance Was well.
出处
《中国基层医药》
CAS
2011年第11期1490-1491,共2页
Chinese Journal of Primary Medicine and Pharmacy
