摘要
目的:观察皮肤保护剂防治鼻咽癌同期放化疗患者急性放射性皮炎的临床疗效及不良反应。方法:54例经病理检查确诊为鼻咽低分化鳞癌初治、有完整资料的患者,27例在第1次放射治疗及化疗后给予皮肤保护剂涂抹为用药组;27例只做常规放射治疗宣教为对照组。两组患者均经6MV-X线三维适形技术照射,并联合顺铂同步化疗。结果:两组患者皮肤反应发生率为100%.两组之间放射性损伤级别有显著性差异(P<0.01)。皮肤反应发生剂量,用药组33.3%(9/27)、对照组96.2%(26/27)出现于照射40 Gy以前。用药组未发现过敏等不良反应。结论:预防性使用皮肤保护剂具有减轻皮肤放射性损伤,提高皮肤对射线的耐受剂量及加速急性放射性皮炎创面愈合的作用。
Objective： To observe the clinical effect and the adverse reaction of Skin Protectants to prevent acute radioactive dermatitis in patients with nasopharyngeal carcinoma.Methods： 54 patients were diagnosed as pooly differentiated nasopharyngeal squamous cell carcinoma that given initial treatment and the data was completed,they were divided into two groups.The treatment group（27 cases） was given Trolamine cream application after the first chemoradiotherapy,while the other 27 serverd as control without Skin Protectants when general and health education program was given.Two groups were illuminated by 6MVX-ray three-dimensional conformal technology with cisplatin concurrent chemotherapy.Results The incidence of skin reaction in control group and treatment group were 100%,the difference between the two groups was significant（P0.01）.The dose of skin reactions occurred： treatment group was 33.3%（9/27）,the control group was 96.2%（26/27 in the irradiation 40 Gy ago.The treatment group was not found allergic or other bad reactions.Conclusion： Trolamine cream can effectively prevent dermal radioactive injury,improve the tolerance dose of radiation in the skin and promote the wounds of acute radioactive dermatitis healing.
出处
《中国医药导报》
CAS
2011年第16期191-192,共2页
China Medical Herald
关键词
皮肤保护剂
鼻咽癌同期放化疗
放射性皮炎
Skin Protectants
Concurrent chemotherapy in Nasopharyngeal Carcinoma
Radioactive dermatitis
作者简介
王琴（1970．9-），女，山东省淄博市人，本科，临床药学专业，淄博市第四人民医院药剂科主管药师；研究方向：临床药学及不良反应监测。
