摘要
目的探讨急性心肌梗死(acute myocardial infarction,AMI)合并高血压患者的临床特点。方法选择90例AMI患者分A组(伴高血压史)、B组(无高血压史)。观察AMI前后血压变化、LVH情况,AMI后2周内UCG测定LVEF、E/A比值、泵功能,血清心肌酶峰CPK、CK-MB测定,血浆AngⅡ、β-EP和CGRP水平的测定,及梗死后心脏事件等。结果 A组血压下降明显,并与基础血压、LVH、泵功能有关;A组发生AMI后AngⅡ、8-EP、降钙素基因相关肽(CGRP)及CPK、CK～MB水平均高于B组;血压下降者LVEF及E/A显著低于血压无下降者,A组泵功能Ⅲ～Ⅳ级发生率高于B组,心脏事件及死亡率也高于B组。结论高血压是冠心病的重要危险因素,高血压发生AMI后71.1%血压下降,这与心功能恶化、LVH、梗死面积大以及血浆AngⅡ、β-EP、CGRP水平更高有关。
Objective To investigate the clinical characters of patients with acute myocardial infarction （AMI） and hypertension, Methods 90 AMI patients are divided into two groups： group A（ AMI with hypertension ） and group B （AMI without hypertension ）. The experiment is designed to study the pre - AMI blood pressure and the post - AMI blood pressure, the fluctuation for LVH, the ratio of LVEF aad E/A calculated by UGG within two weeks after AMI, the pump function, the recording for myocardial enzymes CPK and CK - MB ,the recording for blood AngⅡ,β-EP and CGRP level and the cardiae e- vents after myocardial infarction. Results There is an obvious decrease in the blood pressure for A group ; and it is associated with the basie blood pressure, LVH and the pump function. After the AMI, the AngⅡ,β-EP, calcitonin gene,CRGP,CPK, CK - MB level for A group are higher than that of B group counterparts. Those blood pressure decrease have profound lower LVEF and E/A than their counterparts whose blood pressure maintain the same level. The incidence rate regarding the pump function Ⅲ-Ⅳ for A group is higher than B group. Meanwhile, the myocardial infarction morbidity is higher than B group. Conclusion The high risk for the patients having hypertension and coronary artery disease. 71.1% patients recorded as having hypertension will have a decreased blood pressure after AMI. This if linked with the heart deterioration, LVH, large area of infarction, as well as the higher level of blood AngⅡ,β-EP, CGRP.
出处
《中国医学创新》
CAS
2011年第14期1-4,共4页
Medical Innovation of China
关键词
急性心肌梗死
高血压
临床特点
Acute myocardial infarction
Hypertension
Clinical characters
作者简介
通讯作者：杨凯
