摘要
Four rapid spectral comparison methods are introduced in mobile labs.They are conformity test method,general correlation coefficient method,reverse correlation coefficient method and correlation coefficient method using characteristic spectral ranges.The first method is used for tracking the movements of drugs in the distribution channels;the second is used for quickly identify new counterfeit drugs;the last two are used to screen drugs illegally added in Traditional Chinese Medicine （TCM）.The applicability of the four methods is evaluated with counterfeit and authentic drugs.Our results show that these methods can be quickly constructed and used to identify counterfeit drugs accurately.
本文介绍了四种在药品检测车中使用的谱图快速比较方法,即一致性检验、一般相关系数方法、逆向相关系数方法和特征谱段相关系数方法。第一种方法用于药品出厂后的全程质量跟踪,第二种方法用于市场上突发假药的应急检验,最后两种方法用于筛查市场上存在的中成药非法添加化学药类型的假药。本文应用大量真药与假药对四种方法的可行性进行了验证并对四种方法在检测车中的实际使用情况做了详细的介绍。结果表明这四种方法不仅原理简单、建模需要样本量少,还可以快速、实时、准确地鉴别假药。
基金
National Key Technologies R&D Program Foundation of China(Grant No.2008BAI55B06).
作者简介
Correspondingauthor．Tel．：86—10—67095308；fax：86—10-65115148；E—mail：hucq@nicpbp．org．cn
