摘要
颅内动脉瘤是颅内动脉管壁病理性局限性扩张产生的脑血管瘤样突起,位居脑血管疾病病因的第3位,是造成蛛网膜下腔出血的首位病因。颅内动脉瘤的发生、发展和破裂受多种因素影响,其病理机制尚不十分明确。近年来,随着计算机模拟重建、流体力学等诊断技术的不断进步,越来越多的研究表明,血流动力学因素在动脉瘤的形成、生长及破裂过程中起着重要作用。其中,切应力被认为起主导作用。本文通过回顾近年来国内外关于血流动力学的文献,就切应力在血流动力学因素影响颅内动脉瘤发病机制中的作用展开综述。
An intracranial aneurysm is a weakness in the wall of an artery which is thought to be caused by congenital defects in the vascular wall combined with degenerative changes that cause bulging or outpouching of an intracranial blood vessel wall and may eventually lead to rupture.It is the third etiological factor in cerebral vascular diseases（CVD） and is the leading cause of subarachnoid hemorrhage（SAH）.The formation,growth,and configuration of intracranial aneurysms are usually influenced by multiple factors and the pathogenesis is still unclear.In recent years,with the rapid development of diagnostic technique using hydromechanics and numeral simulation of computational fluid dynamics（CFD）,increasing number of studies have demonstrated that internal flow hemodynamics have a crucial effect on the formation,growth,and configuration of intracranial aneurysms,and the wall shear stress（WSS） caused by the rapid changes of blood flow direction continually plays an crucial role in damaging the intima at an aneurysm cavity neck and probably causing the initiation and subsequent progression of most saccular aneurysms.In this term,we mainly overviewed the role of WSS in the effect of hemodynamic factors on the pathogenesis of intracranial aneurysm by reviewing the recent domestic and foreign related researches.
出处
《介入放射学杂志》
CSCD
北大核心
2011年第4期319-324,共6页
Journal of Interventional Radiology
作者简介
通信作者：段传志E—mail：doctor_dtlanZJ@163.com
