CD44水解片段的释放及其功能

Release of CD44-proteolytic Fragments and their Functions——Review

在线阅读下载PDF

导出

摘要 CD44是一种广泛表达的细胞表面黏附分子并参与细胞多种生物活动。CD44在酶作用下可发生有序的蛋白水解。CD44的水解程度与细胞活性有关,其水解后片段包括可溶性CD44(soluble CD44,sCD44)和CD44胞内结构域(CD44 intracellular domain,CD44ICD),二者在细胞生命活动中发挥不同作用。近年对CD44水解及水解后片段进行了深入的研究,本文就CD44水解及水解后片段的功能进行综述。 CD44 is a widely distributed cell-adhesion molecule that participates in a number of biological events.CD44 is proteolytically cleaved by other enzymes and the level of its proteolysis is correlated to the cell activity.The CD44-proteolytic peptides including soluble CD44 and CD44 intracellular domain have different functions in cell events.In recent years,a number of researches found the functions of CD44-proteolytic peptides.In this review,the release of CD44-proteolytic peptides and their functions of these peptides were summarized.

作者陈大燕冯茹

机构地区南方医科大学南方医院血液科

出处《中国实验血液学杂志》 CAS CSCD 2011年第2期554-556,共3页 Journal of Experimental Hematology

关键词 CD44 蛋白水解可溶性CD44 CD44胞内结构域 CD44 proteolysis soluble CD44 CD44 intracellular domain

分类号 R730.2 [医药卫生—肿瘤]

作者简介通讯作者：冯茹，教授．电话：（020）61641613．E—mail：ruth1626@hotmail．com

引文网络
相关文献

参考文献21

1Okamoto I, Kawano Y, Tsuiki H, et al. CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration. Oncogene, 1999 ; 18 ( 7 ) : 1435 - 1446.
2Murakami D, Okamoto I, Nagano O, et al. Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene,2003 ;22(10) :1511 - 1516.
3Pelletier L, Guillanmot P, Freche B, et al. Gamma-secretase- dependent proteolysis of CD44 promotes neoplastic transformation of rat fibroblastic cells. Cancer Res, 2006 ;66 (7) : 3681 - 3687.
4Nagano O, Saya H. Mechanism and biological significance of CD44 cleavage. Cancer Sci ,2004 ;95 (12) :930 - 935.
5Kawano Y, Okamoto I, Murakami D, et al. Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the rho family of small G proteins. J Biol Chem, 2000 ; 275 ( 38 ) : 29628 - 29635.
6Ohno S, Ohno-Nakahara M, Knudson CB, et al. Induction of MMP- 3 by hyaluronan oligosaccharides in temporomandibular joint chondrocytes. J Dent Res,2005 ;84 ( 11 ) : 1005 - 1009.
7Sugahara KN, Hirata T, Hayasaka H, et al. Tumor cells enhance their own CI)44 cleavage and motility by generating hyaluronan fragments. J Biol Chem,2006 ;281 (9) :5861 - 5868.
8Lopez JI, Camenisch TD, Stevens MV, et al. CD44 attenuates metastatic invasion during breast cancer progression. Cancer Res, 2005 ;65 ( 15 ) :6755 - 6763.
9Annaert WG, Levesque L, Craessaerts K, et al. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. J Cell Biol, 1999, 147(2) :277 -294.
10Zhang YW, Xu H. Substrate check of gamma-secretase. Nat Struct Mol Biol,2010 ; 17 (2) : 140 - 141.

1李学彦,蒋会勇,王雷,林朝胜.血清可溶性CD44在胃癌手术前后变化的研究[J].中国冶金工业医学杂志,2009,26(6):727-728. 被引量：1
2陈萍,傅晋翔,孙兰云,李军,虞斐.成人急性淋巴细胞白血病患者血浆中可溶性CD44水平变化及其意义[J].中国血液流变学杂志,2002,12(2):107-109. 被引量：1
3陈萍,傅晋翔,孙兰云,李军,虞斐.恶性淋巴增殖性疾病患者血浆可溶性CD44水平的检测[J].江苏医药,2002,28(10):781-782.
4孙艳花,陈子兴,江森,岑建农,姚利.急性白血病患者脑脊液中可溶性CD44的测定及其在中枢神经系统白血病诊断中的意义[J].中华血液学杂志,2011,32(1):57-58. 被引量：5
5郭亚军,谢天培,施乐华,沈峰,王皓,刘彦君,钱卫珠,吴孟超.可溶性CD44－免疫球蛋白融合蛋白抑制肿瘤的体内生长[J].第二军医大学学报,1996,17(4):316-319.
6朱颖军,高企贤,曲芃,郭成秀,王仲兰.卵巢上皮性癌中可溶性CD44的测定[J].中国实用妇科与产科杂志,2000,16(6):363-365. 被引量：4
7许彤,阎慧丽,许挺.miRNA与肿瘤的研究进展[J].医药论坛杂志,2015,36(5):172-174. 被引量：2
8徐立友,战志勇,等.可溶性CD54与CD44在结直肠癌中的表达及其临床意义[J].中国肛肠病杂志,2001,21(8):3-5.
9覃宇奇,覃冠平,蓝川,韦爱芳.乙醛脱氢酶1、CD133在鼻咽癌组织中的表达及临床意义[J].疑难病杂志,2015,14(6):590-592. 被引量：5
10姚和瑞,李志华,罗永辉,苏逢锡.CD44与乳腺癌化疗耐药的关系研究[J].中华普通外科学文献（电子版）,2009,3(4):12-15. 被引量：6

中国实验血液学杂志

2011年第2期

浏览历史

内容加载中请稍等...

CD44水解片段的释放及其功能

参考文献21

相关作者

相关机构

相关主题

浏览历史