摘要
目的:探讨超微粉碎制备大黄配方颗粒(颗粒)与大黄标准煎剂(煎剂)、大黄细粉剂(细粉)和大黄超微粉剂(超微粉)促小肠推进的药理等效性。方法:同批次中药饮片制备的大黄煎剂、细粉、超微粉和颗粒以不同剂量组灌胃给药一次,计算小鼠小肠墨汁推进率(CPRI)。结果:大黄煎剂、细粉、超微粉和颗粒所有剂量组CPRI较对照组均有不同程度的显著性增加(P<0.05);量效曲线分别采用复合、复合、幂指数、复合曲线拟合;大黄配方颗粒效价(mg/kg)=34.354+0.055×大黄煎剂(CPRI:45.28%-50.09%)=40.765+0.103×大黄细粉(CPRI:45.28%-54.18%)=60.088+0.532×大黄超微粉(CPRI:45.28%-68.63%);在121.88-3 900mg/kg剂量(2-5-20倍临床等效剂量)范围内,大黄颗粒效应(%)=-14.243+1.762×大黄煎剂=-11.939+1.578×大黄细粉=1.550+1.055×大黄超微粉。结论:大黄颗粒药理等效性>超微粉>细粉>煎剂。
Objective：To investigate the pharmacological equivalences of the four different formulations of Rhubarb：ultra-fined-dispensing-granule（uDG）,standard-decoction（SD）,fine powder（FD） and ultrafine powder（UP）.Methods：Both the positive control drug and the four different formulations of Rhubarb which came from the same batch,were orally administered to mice only once with different doses,and the carbo propulsion rate of intestine（CPRI） was calculated.Results：Compared with the control group,propulsion rate of intestine in the positive control drug group and in all dose groups of the four formulations of Rhubarb were significantly increased（P〈0.05）.Exponential curve were used to fitting the dose-response curve of Rhubarb ultrafine-powderm,but the compound curve were selected for the others＇formulations of Rhubarb.Potency of uDG（mg/kg）=34.354＋0.055×SD（CPRI：45.28-50.09%）=40.765＋0.103×FD（45.28-54.18%%）=60.088＋0.532×UP（CPRI：45.28-68.63%）;in 121.88-3900 mg/kg dose（2-5-20 times clinic equivalent dosage）range,effects of uDG（%）=-14.243＋1.762×SD=-11.939＋1.578×FD=1.550＋1.055×UP.Conclusion：Pharmacological equivalent of uDGUPFD SD.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2011年第5期1051-1057,共7页
China Journal of Traditional Chinese Medicine and Pharmacy
关键词
药理等效性
大黄超微粉碎配方颗粒
大黄标准煎剂
大黄细粉剂
大黄超微粉剂
小肠墨汁推进率
小鼠
Pharmacological equivalence
Rhubarb ultra-fined-dispensing-granule
Rhubarb tandard-decoction
Rhubarbfine powder
Rhubarb ultrafine powder
Carbo propulsion rate of intestine
Mice
作者简介
通讯作者：赵自明，广东省广州市恒福路60号中医研究所中药药理毒理研究室，邮编：510095，电话：020—83482266E。mail：zzm8661773@yahoo．com．cn
