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外周血未染色大细胞在骨髓增生异常综合征早期诊断中的价值 被引量:2

The Value of large unstained cell in peripheral blood in the early diagnosis for myelodysplastic syndrome
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摘要 目的通过测定外周血未染色大细胞比率(LUC%),以期提高骨髓增生异常综合征(MDS)的早期诊断率。方法选取我院58例确诊为MDS的患者,并设30例对照病例,比较外周血中LUC%和骨髓形态学报告。结果 58例MDS患者中54例(93.1%)外周血LUC%高于正常,其中有45例(83.3%)经初次骨髓穿刺诊断为MDS,9例(16.7%)经2~3次骨髓穿刺诊断为MDS。对照组30例中有1例(3.3%)外周血LUC%高于正常者。结论外周血LUC%的增高有早期诊断MDS的价值。 Objective The ratio of large non-stainned cells in peripheral blood(LUC%) is measured to improve the rate of early diagnosis of myelodysplastic syndrome(MDS).Methods The LUC% of peripheral blood and the reports of bone marrow morphology of 58 patients diagnosed with MDS in our hospital were investigated comparing with 30 control cases.Results The LUC% of peripheral blood of 54(93.1%) patients from 58 cases of MDS was higher than that of control.45 cases(83.3%) from the above 54 patients were diagnosed as MDS by means of initial bone marrow biopsy,and 9 patients(16.7%) were affirmed to be MDS after the bone marrow puncture for 2 to 3 times.There was only one case(3.3%) that the LUC% of peripheral blood was higher than that of the normal in 30 patients in control group.Conclusion The increase of the LUC% of peripheral blood is value of early diagnosis for MDS.
出处 《中国实用医药》 2011年第11期3-4,共2页 China Practical Medicine
关键词 骨髓增生异常综合征 早前诊断 价值 Myelodysplastic syndrome Early diagnosis Value
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参考文献6

  • 1Watanabe-Okochi N,Kitaura J,Ono R,et al.AML1 mutations induced MDS and MDS/AML in a mouse BMT model.Blood,2008,111(8):4297-4308.
  • 2Leitch HA,Vickars LM.Supportive care and chelation therapy in MDS:are we saving lives or just loweringiron? Hematology,2009:664-672.
  • 3Malins DC,Anderson KM,Polissar NL,et al.Models of granulocyte DNA structure are highly predictive of myelodysplastic syndrome.Proc Natl Acad Sci U S A,2004,101(14):5008-5011.
  • 4Poul Thirup.LUC,what is that? Clinical Chemistry,1999,45:1100-1100.
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