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DNA甲基化在结直肠癌诊疗中的应用前景 被引量：3

Foreground of DNA methylation in diagnosis and therapy of colorectal cancer
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摘要 目前认为结直肠癌的发生是在环境因素的作用下通过遗传学和表观遗传学的累积性改变所致。表观遗传学修饰,特别是基因启动子区域的DNA甲基化,被认为是肿瘤中普遍发生的分子改变。因此可通过检测基因的异常甲基化等表观遗传学改变对结直肠癌进行预防、早期诊断、临床治疗及预后评价。本文论述了结直肠癌相关基因甲基化状态的研究进展以及表观遗传学的临床应用,目的在于探讨表观遗传学在结直肠癌早期诊断及治疗中的意义。 Colotectal cancer arises as a consequence of the accumulation of genetic and epigenetic alterations in colonic mucous epithelial cells.Epigenetic changes,particularly DNA methylation is recognized as common molecular alterations in human tumors.It may be used as colorectal cancer detection or prognosis markers.In this review,we summarized the characteristics of epigenetic changes and clinical applications in colorectal cancer.
作者 景坤玉 薛乐勋 郭明洲
机构地区 郑州大学生物工程系 中国人民解放军总医院消化科
出处 《胃肠病学和肝病学杂志》 CAS 2011年第3期201-205,共5页 Chinese Journal of Gastroenterology and Hepatology
基金 国家重点基础研究发展计划(973计划)课题资助(编号:2010CB912802)
关键词 结直肠癌 表观遗传学 DNA甲基化 组蛋白修饰 非编码RNA Colorectal cancer Epigenetics DNA methylation Histone modification Noncoding RNA
分类号 R735.34 [医药卫生—肿瘤]
作者简介 景坤玉，硕士研究生，研究方向：肿瘤标志物与基因工程。E-mail：jky19@163．com 通讯作者：薛乐勋，教授，从事肿瘤分子生物学研究。E-mail：xuelx@zzu．edu．cn： 郭明洲，研究员，从事消化道肿瘤表观遗传学研究。E-mail：mzguol@gmail．com
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参考文献10

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二级参考文献10

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胃肠病学和肝病学杂志
2011年 第3期

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