2Jlie GH. Regulation of 5-HT1A receptor function in brain following ag- onist or antidepressant administration [ J 1. Life Sciences, 2003,72 ( 15 ) : 1665-1672.
3Schloss P, Henn FA. New insights into themechanisms of antidepres- sant therapy [ J ], Pharmacol Ther,2004,102 ( 1 ) :47-60.
4ClausN, Kristin C. Selective modulation of Ca2 + influx pathways by 5-HT regulates synaptic long-term plasticity in the hippocampus [J ]. Brain Research,2005, 1037(1-2) : 187-193.
5H jorth S, Bengtsson H J, Kullberg A, et al. Serotonin autoreceptor function and antidepressant drug action[J]. Journal of Psychopharma- cology, 2000,14(2) : 177-185.
6Abert PR, Lemondes. 5-HT1 receptors, gene repression, and depres- sion : guilt by association [ J]. Ncuroscientist,2004,10 ( 6 ) :575-593.
7Sakaue M, Sombonthum P. Postsynaptic 5-hydroxytryptamine 1A re- ceptor- activation increases in vivo dopamine release in rat prefrontal cortex[ J]. J Pharmacology,2000, 129 (5) : 1028-1034.
8Lemonde S, Turecki G, Bakish D, et al. Impaired repression at a 5- Hydrexytryptamine 1A receptor gene polymorphism associated with major depression and suicide [ J]. J Neurosci, 2003, 23 ( 25 ) : 8788 -8799.
9Strobel A, Gutknecht L, Rothe C, et al. Allelic variation in 5-HT1A receptor expression is associated with anxiety-and depression-related- personality traits [ J ]. J Neural Transm ,2003,110 ( 12 ) : 1445-1453.
2[1]File SE. Rencent Developments in Anxiety, Stress, and Depression. Pharmacol Biochem Behav, 1996, 543～12.
3[2]Barnes NM, Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology,1999,381083～1152.
4[3]Suzuki M, Matsuda T, Asano S, et al. Increase of noradrenaline releae in the hypothalamus of freely moving rat by postsynaptic 5-hydroxytryptamine 1A receptor activation. Br J Pharmacol,1995,115703～711.
5[4]Hajos-Korcsok E, Sharp T. Effect of 5-HT(1A) receptor ligands on Fos-like immunoreactivity in rat brain: evidence for activation of noradrenergic transmission. Synapse,1999,34145～153.
6[5]Whale R, Clifford EM, Bhagwagar Z, et al. Decreased sensitivity of 5-HT(1D) receptors in melancholic depression. Br J Psychiatry, 2001,178454～457.
7[6]Lerer B, Macciardi F, Segman RH, et al. Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. Molecule Psychiatry, 2001, 6579～585.
8[7]Boess FG, Riemer C, Bos M, et al. Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells. Neuropharmacology,1997,36713～720.
9[8]Gobbi M, Parotti L, Mennini T. Are 5-hydroxytryptamine7 receptors involved in 3[H] 5-hydroxytryptamine binding to 5-hydroxytryptamine1nonA-nonB receptors in rat hypothalamus? Mol Pharmacol,1996,49556～559.
10[9]Mullins UL, Gianutsos G, Eison AS. Effects of antidepressants on 5-HT7 receptor regulation in the rat hypothalamus. Neuropsychopharmacology,1999, 21352～367.
