摘要
目的:探讨应用胎儿纤维连接蛋白评估抗生素治疗先兆早产的疗效。方法:选择妊娠28～33+6周先兆早产孕妇67例,随机分成两组:研究组35例,连续使用抗生素以及硫酸镁治疗3天;对照组32例,硫酸镁治疗3天,未使用抗生素。检测治疗前、治疗3天后宫颈阴道分泌物中的胎儿纤维连接蛋白(fFN)和血清中的C-反应蛋白(CRP)。结果:(1)研究组保胎成功29例,占82.8%(29/35);对照组保胎成功19例,占59.4%(19/32);比较两组保胎成功率,差异有统计学意义(P<0.05);(2)比较两组治疗后fFN阳性率和CRP值,差异均有统计学意义(P<0.05);(3)比较经治疗后fFN阳性CRP正常组与fFN阴性CRP异常组的妊娠结局,差异有统计学意义(P<0.05)。在预测早产方面,fFN敏感性为78.9%,特异性为87.5%;CRP敏感性为52.6%,特异性为79.1%。结论:胎儿纤维连接蛋白可作为评价先兆早产疗效的一项指标。
Objective：To study the value of using antibiotics in the treatment of threatened preterm labor by fetal fibronectin.Methods：Sixty seven pregnant women with threatened preterm labor between 28 and 33＋6 weeks of gestation were included.They were divided into two groups.35 cases in study group at random,which had been treated continually by the preventing preterm labor therapy including antibiotics and magnesium sulfate for three days.32 cases in control group,which had been treated by the preventing preterm labor therapy with magnesium sulfate but without antibiotics.Cervicovaginal fetal fibronectin（fFN）and C-reactive protein（CRP）in serum were detected before treatment and after three-day treatment respectively.Results：（1）29 cases（82.8%,29/35）in study group and 19 cases（59.4%,19/32）in control group were cured successfully.（2）There were great differences between two groups compared in the success rate（P0.05）.（3）After treatment,the fFN and CRP had significant differences between two groups（P0.05）.Different fFN and CRP pairings had different pregnancy outcome（P0.05）.The fFN had a specificity of 78.9% for delivery within 7 days,and a specificity of 87.5%;comparing with the CRP had a specificity of 52.6% and a specificity of 79.1%.Conclusion：Fetal fibronectin can be an index of evaluation in therapeutic effect of threatened preterm labor.
出处
《现代妇产科进展》
CSCD
北大核心
2011年第3期193-195,共3页
Progress in Obstetrics and Gynecology
作者简介
王蕾蕾（1982-），女，中国医科大学附属盛京医院妇产科主治医师。主要研究方向：妊娠期高血压疾病。
通讯作者Email：shangtao46@yahoo．com.cn
