摘要
背景:目前运用人工生物材料干预软骨损伤后愈合与康复的手段日趋成熟与多样,为半月板康复提供了崭新的研究方向。目的:对半月板运动损伤机制进行探讨,分析生物材料在半月板损伤修复中的作用。方法:由第一作者检索1990/2010 PubMed数据及CNKI数据库,选择文章内容与半月板损伤、人工材料治疗措施等相关的文献。结果与结论:人工生物材料在具体实践运用过程中,由于必须考虑其与人体的生物相容性、形状的匹配、附着性、韧性、强度等,选择理想的植入物较为困难。目前修复半月板应用较多的生物材料主要有透明质酸、胶原、明胶、聚羟乙酸、聚乳酸、聚磷酸钙、不可吸收的聚四氟乙烯、碳素纤维聚合物等。将干细胞定向诱导或经转化生长因子β1基因修饰,通过调节多种细胞的生长和分化,诱导骨髓间充质干细胞向软骨细胞方向分化,并接种于生物支架材料上,为半月板的损伤康复提供了崭新的研究方向。
BACKGROUND：The method of healing and rehabilitation using artificial biomaterial intervention after cartilage injury has been matured and diversified,and provides a new research direction for rehabilitation of meniscus.OBJECTIVE：To explore the mechanism of meniscus sports injury,and to analyze the effect of biomaterial on injury repair of meniscus.METHODS：PubMed database and CNKI database from 1990 to 2010 were retrieved by the first author.The articles related with meniscus injury,treatment of artificial materials were selected.RESULTS AND CONCLUSION：Due to artificial biomaterial and compatibility of human,shape matching,adhesion,toughness,strength,etc.in the progress of specific practice and operation must be considered.The selection of ideal implant is more difficult.At present reparation of meniscu with more biomaterials,including hyaluronic acid,collagen,gelatin,polyglycolic acid（PGA）,polylactic acid,calcium polyphosphate（CPP）,nonassimilable politef,carbon fiber polymer,etc.The stem cells were directionally induced or modified by transforming growth factor β1 gene.By regulating the growth and differentiation of multiple cells,bone marrow mesenchymal stem cells were differentiated into chondrocyte and inoculated in biological scaffolds,provided a new research direction for the injury and rehabilitation of meniscu.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第8期1487-1490,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
作者简介
李晓艳，女，1980年生，河南省济源市人，讲师，硕士，主要从事运动训练与体育保健研究。sqh@hpu．edu．cn
