摘要
目的:观察1型糖尿病(T1DM)初发患儿细胞免疫与胰岛β细胞功能之间的关系。方法:T1DM组23例初发患儿均测定淋巴细胞亚群(T细胞、B细胞及NK细胞)、HbA1c、INS、C-P,正常对照组20例,测定淋巴细胞亚群。结果:T1DM组CD4、CD4/CD8较正常对照组升高(P<0.05);CD8、CD3-CD56+较对照组降低(P<0.05);CD4/CD8比值与HbA1c呈正相关(r=0.9451,P<0.01),而与INS呈负相关(r=-0.1020,P<0.01),与C-P呈负相关(r=-0.6174,P<0.01);CD3-CD56+与HbA1c呈正相关(r=0.1320,P<0.01),而与INS呈正相关(r=-0.0846,P<0.01),与C-P呈负相关(r=-0.3224,P<0.01)。结论:T1DM初发患者CD4、CD4/CD8明显增高,CD8、CD3-CD56+明显降低,提示细胞免疫功能改变与胰岛β细胞功能损伤密切相关。
Objective：To investigate the relationship between cellular immunity and function of islet beta cell in children with type 1 diabetes Newly Diagnosed.Methods：Lymphocyte subsets（T cells,B cells,NK cells）,HbA1c,INS and C-P were detected in diabete group（23 children） with type 1 diabetes newly diagnosed.Lymphocyte subsets were measured in normal control group（20 children）.Results：The CD4 and the CD4/CD8 ratio in diabetes group was higher than that in normal control group（P0.05）.The percentage of CD8 and CD3-CD56＋ decreased compared with that of controls（P0.05）.Both the CD4/CD8 ratio and CD3-CD56＋ were positively correlated with HbA1c.The CD4/CD8 ratio was negatively correlated with INS or C-P.CD3-CD56＋ was positively correlated with INS,but which was negatively correlated with C-P.Conclusions：The percentage of CD4 and the CD4/CD8 ratio in children with type 1 diabetes Newly Diagnosed incresed significantly,while the percentage of CD8 and CD3-CD56＋ decreased significantly,which suggested that the change of cellular immunity was closely related with functional damages of islet beta cell.
出处
《现代生物医学进展》
CAS
2011年第5期922-925,共4页
Progress in Modern Biomedicine
作者简介
乔凌燕（1984-），女，硕士研究生，研究方向为小儿内分泌与遗传病，E-mail：qiao．ling．yan@163．com
通讯作者：李堂，男，主任医师，教授，博士生导师，研究方向为小儿内分泌与遗传病E-mail：litang@qd—public．sd．cninfo．net电话：13506481556
